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Article

Effects of Omega-3 Fatty Acids on Muscle Mass, Muscle Strength and Muscle Performance among the Elderly: A Meta-Analysis

by 1,2,†, 3,4,†, 1,5, 6 and 1,7,*
1
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
2
Department of Dietetics and Nutrition, Heping Fuyou Branch, Taipei City Hospital, Taipei 10065, Taiwan
3
School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan
4
Research Center of Geriatric Nutrition, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan
5
Emergency Department, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan
6
Department of Biomedical Engineering, National Yang-Ming University, Taipei 11221, Taiwan
7
Department of Medical Research, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2020, 12(12), 3739; https://doi.org/10.3390/nu12123739
Received: 12 November 2020 / Revised: 2 December 2020 / Accepted: 2 December 2020 / Published: 4 December 2020
(This article belongs to the Special Issue Omega-3 Polyunsaturated Fatty Acids and Human Health)
There is increasing evidence showing the role of fatty acids and their derived lipid intermediates in the regulation of skeletal muscle mass synthesis and function. However, the role of omega-3 fatty acids remains unclear. Therefore, we conducted a meta-analysis to evaluate the potential effects of omega-3 fatty acids on sarcopenia-related performances among the elderly. Eligible literature and reports of randomized controlled trials were comprehensively searched from the PubMed, Cochrane Library, ClinicalTrials.gov, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases until July 2018. A total of 10 articles were available for the meta-analysis. There were minor benefits for muscle mass gain (0.33 kg; 95% CI: 0.05, 0.62) and timed up and go performance (−0.30 s; 95% CI: −0.43, −0.17). Subgroup analyses regarding muscle mass and walk speed indicated that omega-3 fatty acid supplements at more than 2 g/day may contribute to muscle mass gain (0.67 kg; 95% CI: 0.16, 1.18) and improve walking speed, especially for those receiving more than 6 months of intervention (1.78 m/sec; 95% CI: 1.38, 2.17). Our findings provide some insight into the effects of omega-3 fatty acids on muscle mass, especially for those taking supplements at more than 2 g/day. We also observed that a long period of omega-3 fatty acids supplementation may improve walking speed. View Full-Text
Keywords: docosahexaenoic acid (DHA); elderly; eicosapentaenoic acid (EPA); omega-3 fatty acid; n-3 PUFAs; sarcopenia docosahexaenoic acid (DHA); elderly; eicosapentaenoic acid (EPA); omega-3 fatty acid; n-3 PUFAs; sarcopenia
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MDPI and ACS Style

Huang, Y.-H.; Chiu, W.-C.; Hsu, Y.-P.; Lo, Y.-L.; Wang, Y.-H. Effects of Omega-3 Fatty Acids on Muscle Mass, Muscle Strength and Muscle Performance among the Elderly: A Meta-Analysis. Nutrients 2020, 12, 3739. https://doi.org/10.3390/nu12123739

AMA Style

Huang Y-H, Chiu W-C, Hsu Y-P, Lo Y-L, Wang Y-H. Effects of Omega-3 Fatty Acids on Muscle Mass, Muscle Strength and Muscle Performance among the Elderly: A Meta-Analysis. Nutrients. 2020; 12(12):3739. https://doi.org/10.3390/nu12123739

Chicago/Turabian Style

Huang, Ya-Hui; Chiu, Wan-Chun; Hsu, Yuan-Pin; Lo, Yen-Li; Wang, Yuan-Hung. 2020. "Effects of Omega-3 Fatty Acids on Muscle Mass, Muscle Strength and Muscle Performance among the Elderly: A Meta-Analysis" Nutrients 12, no. 12: 3739. https://doi.org/10.3390/nu12123739

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