Next Article in Journal
Plant Proteins: Assessing Their Nutritional Quality and Effects on Health and Physical Function
Previous Article in Journal
Understanding the Heterogeneity of Obesity and the Relationship to the Brain-Gut Axis
Article

Lactobacillus sakei ADM14 Induces Anti-Obesity Effects and Changes in Gut Microbiome in High-Fat Diet-Induced Obese Mice

Department of Food Science and Biotechnology, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 16419, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(12), 3703; https://doi.org/10.3390/nu12123703
Received: 6 October 2020 / Revised: 28 October 2020 / Accepted: 12 November 2020 / Published: 30 November 2020
(This article belongs to the Section Prebiotics and Probiotics)
The aim of our study was to evaluate the anti-obesity effects of Lactobacillus sakei (L. sakei) ADM14 administration in a high-fat diet-induced obese mouse model and the resulting changes in the intestinal microbiota. Prior to in vivo testing, L. sakei ADM14 was shown to inhibit adipogenesis through in vitro test and genetic analysis. Subsequently, mice were orally administered 0.85% saline supplemented or not with L. sakei ADM14 to high-fat diet group and normal diet group daily. The results showed that administration of L. sakei ADM14 reduced weight gain, epididymal fat expansion, and total blood cholesterol and glucose levels, and significantly decreased expression of lipid-related genes in the epididymal fat pad. Administration of L. sakei ADM14 showed improvement in terms of energy harvesting while restoring the Firmicutes to Bacteroidetes ratio and also increased the relative abundance of specific microbial taxa such as Bacteroides faecichinchillae and Alistipes, which are abundant in non-obese people. L. sakei ADM14 affected the modulation of gut microbiota, altered the strain profile of short-chain fatty acid production in the cecum and enhanced the stimulation of butyrate production. Overall, L. sakei ADM14 showed potential as a therapeutic probiotic supplement for metabolic disorders, confirming the positive changes of in vivo indicators and controlling gut microbiota in a high-fat diet-induced obese mouse model. View Full-Text
Keywords: Lactobacillus sakei; probiotics; anti-obesity; gut microbiome Lactobacillus sakei; probiotics; anti-obesity; gut microbiome
Show Figures

Figure 1

MDPI and ACS Style

Won, S.-M.; Chen, S.; Lee, S.Y.; Lee, K.E.; Park, K.W.; Yoon, J.-H. Lactobacillus sakei ADM14 Induces Anti-Obesity Effects and Changes in Gut Microbiome in High-Fat Diet-Induced Obese Mice. Nutrients 2020, 12, 3703. https://doi.org/10.3390/nu12123703

AMA Style

Won S-M, Chen S, Lee SY, Lee KE, Park KW, Yoon J-H. Lactobacillus sakei ADM14 Induces Anti-Obesity Effects and Changes in Gut Microbiome in High-Fat Diet-Induced Obese Mice. Nutrients. 2020; 12(12):3703. https://doi.org/10.3390/nu12123703

Chicago/Turabian Style

Won, Sung-Min, Siyu Chen, Seo Y. Lee, Kyung E. Lee, Kye W. Park, and Jung-Hoon Yoon. 2020. "Lactobacillus sakei ADM14 Induces Anti-Obesity Effects and Changes in Gut Microbiome in High-Fat Diet-Induced Obese Mice" Nutrients 12, no. 12: 3703. https://doi.org/10.3390/nu12123703

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop