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Article

Effects of High and Low Protein Diets on Inflammatory Profiles in People with Morbid Obesity: A 3-Week Intervention Study

1
Senior Scientist Group Nutrition, Immunity and Metabolism, Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany
2
Institute of Nutritional Science, University of Potsdam, 14558 Nuthetal, Germany
3
Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany
4
German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany
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Clinic for Nutritional Medicine, 10625 Berlin, Germany
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Center for Obesity and Metabolic Surgery, Vivantes Hospital, 13585 Berlin, Germany
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Helios Klinikum Berlin-Buch, 13125 Berlin, Germany
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Department of Endocrinology, Diabetes and Nutrition, Charitè University Medicine Berlin, Campus Benjamin Franklin, 12200 Berlin, Germany
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Research Group Molecular Nutritional Medicine, Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany
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Department Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology-BIPS, 28359 Bremen, Germany
*
Author to whom correspondence should be addressed.
These authors contribution is equally to this work.
Nutrients 2020, 12(12), 3636; https://doi.org/10.3390/nu12123636
Received: 20 October 2020 / Revised: 16 November 2020 / Accepted: 24 November 2020 / Published: 26 November 2020
(This article belongs to the Section Nutritional Immunology)
Nutritional interventions in morbidly obese individuals that effectively reverse a pro-inflammatory state and prevent obesity-associated medical complications are highly warranted. Our aim was to evaluate the effect of high (HP) or low (LP) protein diets on circulating immune-inflammatory biomarkers, including C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-a), interleukin-10 (IL-10), monocyte chemoattractant protein-1 (MCP-1), chemerin, omentin, leptin, total adiponectin, high molecular weight adiponectin, and fetuin-A. With this aim, 18 people with morbid obesity were matched into two hypocaloric groups: HP (30E% protein, n = 8) and LP (10E% protein, n = 10) for three weeks. Biomarkers were measured pre and post intervention and linear mixed-effects models were used to investigate differences. Consuming HP or LP diets resulted in reduced CRP (HP: −2.2 ± 1.0 mg/L, LP: −2.3 ± 0.9 mg/L) and chemerin (HP: −17.9 ± 8.6 ng/mL, LP: −20.0 ± 7.4 ng/mL), with no statistically significant differences by diet arm. Participants following the LP diet showed a more pronounced decrease in leptin (−19.2 ± 6.0 ng/mL) and IL-6 (−0.4 ± 0.1 pg/mL) and an increase in total adiponectin (1.6 ± 0.6 µg/mL). Changes were also observed for the remaining biomarkers to a smaller degree by the HP than the LP hypocaloric diet, suggesting that a LP hypocaloric diet modulates a wider range of immune inflammatory biomarkers in morbidly obese individuals. View Full-Text
Keywords: high protein; low protein; nutritional intervention; morbid obesity; inflammatory biomarkers high protein; low protein; nutritional intervention; morbid obesity; inflammatory biomarkers
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MDPI and ACS Style

Koelman, L.; Markova, M.; Seebeck, N.; Hornemann, S.; Rosenthal, A.; Lange, V.; Pivovarova-Ramich, O.; Aleksandrova, K. Effects of High and Low Protein Diets on Inflammatory Profiles in People with Morbid Obesity: A 3-Week Intervention Study. Nutrients 2020, 12, 3636. https://doi.org/10.3390/nu12123636

AMA Style

Koelman L, Markova M, Seebeck N, Hornemann S, Rosenthal A, Lange V, Pivovarova-Ramich O, Aleksandrova K. Effects of High and Low Protein Diets on Inflammatory Profiles in People with Morbid Obesity: A 3-Week Intervention Study. Nutrients. 2020; 12(12):3636. https://doi.org/10.3390/nu12123636

Chicago/Turabian Style

Koelman, Liselot, Mariya Markova, Nicole Seebeck, Silke Hornemann, Anke Rosenthal, Volker Lange, Olga Pivovarova-Ramich, and Krasimira Aleksandrova. 2020. "Effects of High and Low Protein Diets on Inflammatory Profiles in People with Morbid Obesity: A 3-Week Intervention Study" Nutrients 12, no. 12: 3636. https://doi.org/10.3390/nu12123636

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