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Effect of Probiotic Supplementation on Newborn Birth Weight for Mother with Gestational Diabetes Mellitus or Overweight/Obesity: A Systematic Review and Meta-Analysis

1
Department of Family Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei City 110, Taiwan
2
Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei City 110, Taiwan
3
Nutrition Research Center, Taipei Medical University Hospital, Taipei City 110, Taiwan
4
Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei City, 110, Taiwan
5
Department of Dermatology, Taipei Medical University Hospital, Taipei City 110, Taiwan
6
School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei City 110, Taiwan
7
Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 110, Taiwan
*
Author to whom correspondence should be addressed.
These two authors contributed equally.
Nutrients 2020, 12(11), 3477; https://doi.org/10.3390/nu12113477
Received: 28 September 2020 / Revised: 2 November 2020 / Accepted: 10 November 2020 / Published: 12 November 2020
(This article belongs to the Section Prebiotics and Probiotics)
High birth weight indicates the future risk of obesity and increased fat mass in childhood. Maternal gestational diabetes mellitus (GDM) or overweight are powerful predictors of high birth weight. Studies on probiotic supplementation during pregnancy have reported its benefits in modulating gut microbiota composition and improving glucose and lipid metabolism in pregnant women. Therefore, probiotic intervention during pregnancy was proposed to interrupt the transmission of obesity from mothers to newborns. Thus, we performed a meta-analysis to investigate the effect of probiotic intervention in pregnant women with GDM or overweight on newborn birth weight. We searched PubMed, EMBASE, Cochrane Library, and Web of Science databases up to 18 December 2019. Randomized controlled trials (RCTs) comparing pregnant women with GDM or overweight who received probiotic intervention during pregnancy with those receiving placebo were eligible for the analysis. Newborn birth weights were pooled to calculate the mean difference with a 95% confidence interval (CI). Two reviewers assessed the trial quality and extracted data independently. Seven RCTs involving 1093 participants were included in the analysis. Compared with the placebo, probiotics had little effect on newborn birth weight of pregnant women with GDM or overweight (mean difference = −10.27, 95% CI = −90.17 to 69.63, p = 0.801). The subgroup analysis revealed that probiotic intake by women with GDM decreased newborn birth weight, whereas probiotic intake by obese pregnant women increased newborn birth weight. Thus, no evidence indicates that probiotic intake by pregnant women with GDM or overweight can control newborn birth weight. View Full-Text
Keywords: pregnancy; gut microbiota; probiotics; gestational diabetes mellitus (GDM); obesity; overweight; newborn birth weight pregnancy; gut microbiota; probiotics; gestational diabetes mellitus (GDM); obesity; overweight; newborn birth weight
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MDPI and ACS Style

Wang, C.-C.; Tung, Y.-T.; Chang, H.-C.; Lin, C.-H.; Chen, Y.-C. Effect of Probiotic Supplementation on Newborn Birth Weight for Mother with Gestational Diabetes Mellitus or Overweight/Obesity: A Systematic Review and Meta-Analysis. Nutrients 2020, 12, 3477. https://doi.org/10.3390/nu12113477

AMA Style

Wang C-C, Tung Y-T, Chang H-C, Lin C-H, Chen Y-C. Effect of Probiotic Supplementation on Newborn Birth Weight for Mother with Gestational Diabetes Mellitus or Overweight/Obesity: A Systematic Review and Meta-Analysis. Nutrients. 2020; 12(11):3477. https://doi.org/10.3390/nu12113477

Chicago/Turabian Style

Wang, Chun-Chi, Yu-Tang Tung, Hua-Ching Chang, Chang-Hsien Lin, and Yang-Ching Chen. 2020. "Effect of Probiotic Supplementation on Newborn Birth Weight for Mother with Gestational Diabetes Mellitus or Overweight/Obesity: A Systematic Review and Meta-Analysis" Nutrients 12, no. 11: 3477. https://doi.org/10.3390/nu12113477

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