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Open AccessArticle

Relative Contribution of Gestational Weight Gain, Gestational Diabetes, and Maternal Obesity to Neonatal Fat Mass

1
Department of Neonatology, Bretonneau Hospital, François Rabelais University, 37000 Tours, France
2
INSERM, UMR_S 938 Saint Antoine Research Centre, Sorbonne University, 75012 Paris, France
3
Department of Diabetology, Institute of Cardiometabolism And Nutrition (ICAN), Pitié Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris (APHP), Sorbonne University, 75013 Paris, France
4
Clinic Research Unit, Pitié Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris (APHP), Sorbonne University, 75013 Paris, France
5
Department of Gynaecology and Obstetrics, Pitié Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris (APHP), Sorbonne University, 75013 Paris, France
6
INSERM, Public Health Department, Pierre Louis Institute of Epidemiology and Public Health, AP-HP, Centre of Pharmacoepidémiology (Cephepi), Sorbonne University, 75013 Paris, France
7
Department of Nutrition, Institute of Cardiometbolism And Nutrition (ICAN), Pitié Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris (APHP), Sorbonne University, 75013 Paris, France
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(11), 3434; https://doi.org/10.3390/nu12113434
Received: 28 September 2020 / Revised: 21 October 2020 / Accepted: 2 November 2020 / Published: 9 November 2020
(This article belongs to the Section Nutrition Methodology & Assessment)
Maternal nutritional and metabolic status influence fetal growth. This study investigated the contribution of gestational weight gain (GWG), gestational diabetes (GDM), and maternal obesity to birthweight and newborn body fat. It is a secondary analysis of a prospective study including 204 women with a pregestational body mass index (BMI) of 18.5–24.9 kg/m2 and 219 women with BMI ≥ 30 kg/m2. GDM was screened in the second and third trimester and was treated by dietary intervention, and insulin if required. Maternal obesity had the greatest effect on skinfolds (+1.4 mm) and cord leptin (+3.5 ng/mL), but no effect on birthweight. GWG was associated with increased birthweight and skinfolds thickness, independently from GDM and maternal obesity. There was an interaction between third trimester weight gain and GDM on birthweight and cord leptin, but not with maternal obesity. On average, +1 kg in third trimester was associated with +13 g in birthweight and with +0.64 ng/mL in cord leptin, and a further 32 g and 0.89 ng/mL increase in diabetic mothers, respectively. Maternal obesity is the main contributor to neonatal body fat. There is an independent association between third trimester weight gain, birthweight, and neonatal body fat, enhanced by GDM despite intensive treatment. View Full-Text
Keywords: neonatal fat mass; leptin; birthweight; obesity; diabetes neonatal fat mass; leptin; birthweight; obesity; diabetes
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MDPI and ACS Style

Mitanchez, D.; Jacqueminet, S.; Lebbah, S.; Dommergues, M.; Hajage, D.; Ciangura, C. Relative Contribution of Gestational Weight Gain, Gestational Diabetes, and Maternal Obesity to Neonatal Fat Mass. Nutrients 2020, 12, 3434. https://doi.org/10.3390/nu12113434

AMA Style

Mitanchez D, Jacqueminet S, Lebbah S, Dommergues M, Hajage D, Ciangura C. Relative Contribution of Gestational Weight Gain, Gestational Diabetes, and Maternal Obesity to Neonatal Fat Mass. Nutrients. 2020; 12(11):3434. https://doi.org/10.3390/nu12113434

Chicago/Turabian Style

Mitanchez, Delphine; Jacqueminet, Sophie; Lebbah, Said; Dommergues, Marc; Hajage, David; Ciangura, Cécile. 2020. "Relative Contribution of Gestational Weight Gain, Gestational Diabetes, and Maternal Obesity to Neonatal Fat Mass" Nutrients 12, no. 11: 3434. https://doi.org/10.3390/nu12113434

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