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ω-3 Polyunsaturated Fatty Acids on Colonic Inflammation and Colon Cancer: Roles of Lipid-Metabolizing Enzymes Involved

1
Department of Food Science, University of Massachusetts, Amherst, MA 01002, USA
2
Department of Food Science and Technology, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, China
3
Department of Entomology and Comprehensive Cancer Center, University of California, Davis, CA 95616, USA
4
Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA 01002, USA
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(11), 3301; https://doi.org/10.3390/nu12113301
Received: 23 September 2020 / Revised: 22 October 2020 / Accepted: 24 October 2020 / Published: 28 October 2020
(This article belongs to the Special Issue Omega-3 Polyunsaturated Fatty Acids and Human Health)
Substantial human and animal studies support the beneficial effects of ω-3 polyunsaturated fatty acids (PUFAs) on colonic inflammation and colorectal cancer (CRC). However, there are inconsistent results, which have shown that ω-3 PUFAs have no effect or even detrimental effects, making it difficult to effectively implement ω-3 PUFAs for disease prevention. A better understanding of the molecular mechanisms for the anti-inflammatory and anticancer effects of ω-3 PUFAs will help to clarify their potential health-promoting effects, provide a scientific base for cautions for their use, and establish dietary recommendations. In this review, we summarize recent studies of ω-3 PUFAs on colonic inflammation and CRC and discuss the potential roles of ω-3 PUFA-metabolizing enzymes, notably the cytochrome P450 monooxygenases, in mediating the actions of ω-3 PUFAs. View Full-Text
Keywords: ω-3 PUFAs; colonic inflammation; colorectal cancer; eicosanoids; cytochrome P450 monooxygenases; soluble epoxide hydrolase ω-3 PUFAs; colonic inflammation; colorectal cancer; eicosanoids; cytochrome P450 monooxygenases; soluble epoxide hydrolase
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MDPI and ACS Style

Tu, M.; Wang, W.; Zhang, G.; Hammock, B.D. ω-3 Polyunsaturated Fatty Acids on Colonic Inflammation and Colon Cancer: Roles of Lipid-Metabolizing Enzymes Involved. Nutrients 2020, 12, 3301. https://doi.org/10.3390/nu12113301

AMA Style

Tu M, Wang W, Zhang G, Hammock BD. ω-3 Polyunsaturated Fatty Acids on Colonic Inflammation and Colon Cancer: Roles of Lipid-Metabolizing Enzymes Involved. Nutrients. 2020; 12(11):3301. https://doi.org/10.3390/nu12113301

Chicago/Turabian Style

Tu, Maolin; Wang, Weicang; Zhang, Guodong; Hammock, Bruce D. 2020. "ω-3 Polyunsaturated Fatty Acids on Colonic Inflammation and Colon Cancer: Roles of Lipid-Metabolizing Enzymes Involved" Nutrients 12, no. 11: 3301. https://doi.org/10.3390/nu12113301

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