A Genome-Wide Association Study Identifies the Association between the 12q24 Locus and Black Tea Consumption in Japanese Populations
by
Kyohei Furukawa 1
, 
Maki Igarashi 1,2, Huijuan Jia 1,*, Shun Nogawa 3, Kaoru Kawafune 3, Tsuyoshi Hachiya 3,4, Shoko Takahashi 3, Kenji Saito 1,3 and Hisanori Kato 1,*
Kyohei Furukawa 1, Maki Igarashi 1,2, Huijuan Jia 1,*, Shun Nogawa 3, Kaoru Kawafune 3, Tsuyoshi Hachiya 3,4, Shoko Takahashi 3, Kenji Saito 1,3 and Hisanori Kato 1,*
1
Health Nutrition, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
2
Department of Molecular Endocrinology, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan
3
Research and Development Department, Genequest Inc., 5-29-11 Siba, Minato-ku, Tokyo 108-0014, Japan
4
Department of Genomic Data Analysis Service, Genome Analytics Japan Inc., 15-1-3205 Toyoshima-cho, Shinjuku-ku, Tokyo 162-0067, Japan
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(10), 3182; https://doi.org/10.3390/nu12103182
Received: 15 September 2020 / Revised: 9 October 2020 / Accepted: 10 October 2020 / Published: 18 October 2020
(This article belongs to the Special Issue Genomics and Personalized Nutrition)
Several genome-wide association studies (GWASs) have reported the association between genetic variants and the habitual consumption of foods and drinks; however, no association data are available regarding the consumption of black tea. The present study aimed to identify genetic variants associated with black tea consumption in 12,258 Japanese participants. Data on black tea consumption were collected by a self-administered questionnaire, and genotype data were obtained from a single nucleotide polymorphism array. In the discovery GWAS, two loci met suggestive significance (p < 1.0 × 10−6). Three genetic variants (rs2074356, rs144504271, and rs12231737) at 12q24 locus were also significantly associated with black tea consumption in the replication stage (p < 0.05) and during the meta-analysis (p < 5.0 × 10−8). The association of rs2074356 with black tea consumption was slightly attenuated by the additional adjustment for alcohol drinking frequency. In conclusion, genetic variants at the 12q24 locus were associated with black tea consumption in Japanese populations, and the association is at least partly mediated by alcohol drinking frequency.
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Keywords:
12q24 locus; single nucleotide polymorphism; black tea; genome-wide association study; drinking frequency
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Furukawa, K.; Igarashi, M.; Jia, H.; Nogawa, S.; Kawafune, K.; Hachiya, T.; Takahashi, S.; Saito, K.; Kato, H. A Genome-Wide Association Study Identifies the Association between the 12q24 Locus and Black Tea Consumption in Japanese Populations. Nutrients 2020, 12, 3182.
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