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Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications?

1
Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University, Viale Regina Elena 324, 00161 Rome, Italy
2
Center for Gender-Specific Medicine, Gender Specific Prevention and Health Unit, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy
3
Oncogenomic Unit, Department of Experimental Medicine, Sapienza University, Viale Regina Elena 324, 00161 Rome, Italy
4
Department of Experimental Medicine, 2nd Section of Cell Pathology, Sapienza University, Viale Regina Elena 324, 00161 Rome, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(10), 3179; https://doi.org/10.3390/nu12103179
Received: 22 September 2020 / Revised: 8 October 2020 / Accepted: 12 October 2020 / Published: 17 October 2020
(This article belongs to the Special Issue Dietary Curcumin and Health Effects)
Curcumin, the main polyphenol contained in turmeric root (Curcuma longa), has played a significant role in medicine for centuries. The growing interest in plant-derived substances has led to increased consumption of them also in pregnancy. The pleiotropic and multi-targeting actions of curcumin have made it very attractive as a health-promoting compound. In spite of the beneficial effects observed in various chronic diseases in humans, limited and fragmentary information is currently available about curcumin’s effects on pregnancy and pregnancy-related complications. It is known that immune-metabolic alterations occurring during pregnancy have consequences on both maternal and fetal tissues, leading to short- and long-term complications. The reported anti-inflammatory, antioxidant, antitoxicant, neuroprotective, immunomodulatory, antiapoptotic, antiangiogenic, anti-hypertensive, and antidiabetic properties of curcumin appear to be encouraging, not only for the management of pregnancy-related disorders, including gestational diabetes mellitus (GDM), preeclampsia (PE), depression, preterm birth, and fetal growth disorders but also to contrast damage induced by natural and chemical toxic agents. The current review summarizes the latest data, mostly obtained from animal models and in vitro studies, on the impact of curcumin on the molecular mechanisms involved in pregnancy pathophysiology, with the aim to shed light on the possible beneficial and/or adverse effects of curcumin on pregnancy outcomes. View Full-Text
Keywords: curcumin; pregnancy; pregnancy complications; postpartum depression; fetal development; preterm birth; adverse effects curcumin; pregnancy; pregnancy complications; postpartum depression; fetal development; preterm birth; adverse effects
MDPI and ACS Style

Filardi, T.; Varì, R.; Ferretti, E.; Zicari, A.; Morano, S.; Santangelo, C. Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications? Nutrients 2020, 12, 3179.

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