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Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype

1
Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, 28029 Madrid, Spain
2
Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, 28029 Madrid, Spain
3
GEICAM Spanish Breast Cancer Group, 28703 Madrid, Spain
4
Instituto Valenciano de Oncología, 46009 Valencia, Spain
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Hospital Universitario Virgen Del Rocio, 41013 Sevilla, Spain
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Hospital Universitario Puerta del Mar, 11009 Cádiz, Spain
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Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), 11009 Cádiz, Spain
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Hospital Clínico Universitario de Valencia, 46010 Valencia, Spain
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Biomedical Research Institute INCLIVA, 46010 Valencia, Spain
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CIBERONC, ISCIII, 28029 Madrid, Spain
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Analytical Chemistry Department, Universidad de Córdoba, 14071 Córdoba, Spain
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Maimónides Institute of Biomedical Research (IMIBIC), Reina Sofia University Hospital, University of Córdoba, 14071 Córdoba, Spain
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CIBERFES, ISCIII, 28029 Madrid, Spain
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Medical Oncology Unit, Complejo Hospitalario Universitario A Coruña, 15006 A Coruña, Spain
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Complejo Hospitalario de Jaén, 23007 Jaén, Spain
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Centro Oncológico de Galicia, 15009 A Coruña, Spain
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Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón, 50009 Zaragoza, Spain
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Faculty of Medicine, University of Alcalá, Alcalá de Henares, 28871 Madrid, Spain
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Hospital Clínico San Carlos, 28040 Madrid, Spain
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Medical Oncology, Hospital Clínic Barcelona, 08036 Barcelona, Spain
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Translational Genomics and Targeted Therapeutics, Institut d’Investigacions Biomèdiques Pi i Sunyer-IDIBAPS, 08036 Barcelona, Spain
22
Hospital Marqués de Valdecilla, 39008 Santander, Spain
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Hospital Clínico Universitario Lozano Blesa, 50009 Zaragoza, Spain
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Hospital Arnau de Vilanova, 46015 Valencia, Spain
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Hospital General Yagüe, 09005 Burgos, Spain
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Hospital General de Vic, 08500 Barcelona, Spain
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Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain
28
Instituto Investigación Sanitaria Gregorio Marañón, Universidad Complutense, 28007 Madrid, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2020, 12(10), 3132; https://doi.org/10.3390/nu12103132
Received: 26 August 2020 / Revised: 6 October 2020 / Accepted: 8 October 2020 / Published: 14 October 2020
(This article belongs to the Section Nutritional Epidemiology)
This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases and healthy women pairs. Serum PL-FA percentages were measured by gas chromatography-mass spectrometry. Conditional and multinomial logistic regression models were used to quantify the association of PL-FA tertiles with BC risk, overall and by pathological subtype (luminal, HER2+ and triple negative). Stratified analyses by body mass index and menopausal status were also performed. Serum PL-FAs were measured in 795 (78%) pairs. Women with high serum levels of stearic acid (odds ratio (OR)T3vsT1 = 0.44; 95% confidence interval (CI) = 0.30–0.66), linoleic acid (ORT3vsT1 = 0.66; 95% CI = 0.49–0.90) and arachidonic to dihomo-γ-linolenic acid ratio (OR T3vsT1 = 0.64; 95% CI = 0.48–0.84) presented lower BC risk. Participants with high concentrations of palmitoleic acid (ORT3vsT1 = 1.65; 95% CI = 1.20–2.26), trans-ruminant palmitelaidic acid (ORT3vsT1 = 1.51; 95% CI = 1.12–2.02), trans-industrial elaidic acid (ORT3vsT1 = 1.52; 95% CI = 1.14–2.03), and high oleic to stearic acid ratio (ORT3vsT1 = 2.04; 95% CI = 1.45–2.87) showed higher risk. These associations were similar in all BC pathological subtypes. Our results emphasize the importance of analyzing fatty acids individually, as well as the desaturase activity indices. View Full-Text
Keywords: breast neoplasm; breast cancer subtypes; desaturation indices; fats; EpiGEICAM breast neoplasm; breast cancer subtypes; desaturation indices; fats; EpiGEICAM
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MDPI and ACS Style

Lope, V.; Guerrero-Zotano, Á.; Casas, A.; Baena-Cañada, J.M.; Bermejo, B.; Pérez-Gómez, B.; Criado-Navarro, I.; Antolín, S.; Sánchez-Rovira, P.; Ramos-Vázquez, M.; Antón, A.; Castelló, A.; García-Saénz, J.Á.; Muñoz, M.; de Juan, A.; Andrés, R.; Llombart-Cussac, A.; Hernando, B.; Franquesa, R.M.; Caballero, R.; Priego-Capote, F.; Martín, M.; Pollán, M. Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype. Nutrients 2020, 12, 3132.

AMA Style

Lope V, Guerrero-Zotano Á, Casas A, Baena-Cañada JM, Bermejo B, Pérez-Gómez B, Criado-Navarro I, Antolín S, Sánchez-Rovira P, Ramos-Vázquez M, Antón A, Castelló A, García-Saénz JÁ, Muñoz M, de Juan A, Andrés R, Llombart-Cussac A, Hernando B, Franquesa RM, Caballero R, Priego-Capote F, Martín M, Pollán M. Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype. Nutrients. 2020; 12(10):3132.

Chicago/Turabian Style

Lope, Virginia; Guerrero-Zotano, Ángel; Casas, Ana; Baena-Cañada, José M.; Bermejo, Begoña; Pérez-Gómez, Beatriz; Criado-Navarro, Inmaculada; Antolín, Silvia; Sánchez-Rovira, Pedro; Ramos-Vázquez, Manuel; Antón, Antonio; Castelló, Adela; García-Saénz, José Á.; Muñoz, Montserrat; de Juan, Ana; Andrés, Raquel; Llombart-Cussac, Antonio; Hernando, Blanca; Franquesa, Rosa M.; Caballero, Rosalia; Priego-Capote, Feliciano; Martín, Miguel; Pollán, Marina. 2020. "Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype" Nutrients 12, no. 10: 3132.

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