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Nutrients
Volume 12
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10.3390/nu12103132
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Open AccessArticle

Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype

by
Virginia Lope
1,2,3,*,
Ángel Guerrero-Zotano
3,4,
Ana Casas
3,5,
José Manuel Baena-Cañada
3,6,7,
Begoña Bermejo
3,8,9,10,
Beatriz Pérez-Gómez
1,2,3,
Inmaculada Criado-Navarro
11,12,13,
Silvia Antolín
3,14,
Pedro Sánchez-Rovira
3,15,
Manuel Ramos-Vázquez
3,16,
Antonio Antón
3,17,
Adela Castelló
1,2,18,
José Ángel García-Saénz
3,19,
Montserrat Muñoz
3,20,21,
Ana de Juan
3,22,
Raquel Andrés
3,23,
Antonio Llombart-Cussac
3,24,
Blanca Hernando
3,25,
Rosa María Franquesa
3,26,
Rosalia Caballero
3,
Feliciano Priego-Capote
11,12,13,
Miguel Martín
3,10,27,28,† and
Marina Pollán
1,2,3,†
1
Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, 28029 Madrid, Spain
2
Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, 28029 Madrid, Spain
3
GEICAM Spanish Breast Cancer Group, 28703 Madrid, Spain
4
Instituto Valenciano de Oncología, 46009 Valencia, Spain
5
Hospital Universitario Virgen Del Rocio, 41013 Sevilla, Spain
6
Hospital Universitario Puerta del Mar, 11009 Cádiz, Spain
7
Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), 11009 Cádiz, Spain
8
Hospital Clínico Universitario de Valencia, 46010 Valencia, Spain
9
Biomedical Research Institute INCLIVA, 46010 Valencia, Spain
10
CIBERONC, ISCIII, 28029 Madrid, Spain
11
Analytical Chemistry Department, Universidad de Córdoba, 14071 Córdoba, Spain
12
Maimónides Institute of Biomedical Research (IMIBIC), Reina Sofia University Hospital, University of Córdoba, 14071 Córdoba, Spain
13
CIBERFES, ISCIII, 28029 Madrid, Spain
14
Medical Oncology Unit, Complejo Hospitalario Universitario A Coruña, 15006 A Coruña, Spain
15
Complejo Hospitalario de Jaén, 23007 Jaén, Spain
16
Centro Oncológico de Galicia, 15009 A Coruña, Spain
17
Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón, 50009 Zaragoza, Spain
18
Faculty of Medicine, University of Alcalá, Alcalá de Henares, 28871 Madrid, Spain
19
Hospital Clínico San Carlos, 28040 Madrid, Spain
20
Medical Oncology, Hospital Clínic Barcelona, 08036 Barcelona, Spain
21
Translational Genomics and Targeted Therapeutics, Institut d’Investigacions Biomèdiques Pi i Sunyer-IDIBAPS, 08036 Barcelona, Spain
22
Hospital Marqués de Valdecilla, 39008 Santander, Spain
23
Hospital Clínico Universitario Lozano Blesa, 50009 Zaragoza, Spain
24
Hospital Arnau de Vilanova, 46015 Valencia, Spain
25
Hospital General Yagüe, 09005 Burgos, Spain
26
Hospital General de Vic, 08500 Barcelona, Spain
27
Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain
28
Instituto Investigación Sanitaria Gregorio Marañón, Universidad Complutense, 28007 Madrid, Spain
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nutrients 2020, 12(10), 3132; https://doi.org/10.3390/nu12103132
Received: 26 August 2020 / Revised: 6 October 2020 / Accepted: 8 October 2020 / Published: 14 October 2020
(This article belongs to the Section Nutritional Epidemiology)
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Abstract

This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases and healthy women pairs. Serum PL-FA percentages were measured by gas chromatography-mass spectrometry. Conditional and multinomial logistic regression models were used to quantify the association of PL-FA tertiles with BC risk, overall and by pathological subtype (luminal, HER2+ and triple negative). Stratified analyses by body mass index and menopausal status were also performed. Serum PL-FAs were measured in 795 (78%) pairs. Women with high serum levels of stearic acid (odds ratio (OR)T3vsT1 = 0.44; 95% confidence interval (CI) = 0.30–0.66), linoleic acid (ORT3vsT1 = 0.66; 95% CI = 0.49–0.90) and arachidonic to dihomo-γ-linolenic acid ratio (OR T3vsT1 = 0.64; 95% CI = 0.48–0.84) presented lower BC risk. Participants with high concentrations of palmitoleic acid (ORT3vsT1 = 1.65; 95% CI = 1.20–2.26), trans-ruminant palmitelaidic acid (ORT3vsT1 = 1.51; 95% CI = 1.12–2.02), trans-industrial elaidic acid (ORT3vsT1 = 1.52; 95% CI = 1.14–2.03), and high oleic to stearic acid ratio (ORT3vsT1 = 2.04; 95% CI = 1.45–2.87) showed higher risk. These associations were similar in all BC pathological subtypes. Our results emphasize the importance of analyzing fatty acids individually, as well as the desaturase activity indices. View Full-Text
Keywords: breast neoplasm; breast cancer subtypes; desaturation indices; fats; EpiGEICAM breast neoplasm; breast cancer subtypes; desaturation indices; fats; EpiGEICAM
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MDPI and ACS Style

Lope, V.; Guerrero-Zotano, Á.; Casas, A.; Baena-Cañada, J.M.; Bermejo, B.; Pérez-Gómez, B.; Criado-Navarro, I.; Antolín, S.; Sánchez-Rovira, P.; Ramos-Vázquez, M.; Antón, A.; Castelló, A.; García-Saénz, J.Á.; Muñoz, M.; de Juan, A.; Andrés, R.; Llombart-Cussac, A.; Hernando, B.; Franquesa, R.M.; Caballero, R.; Priego-Capote, F.; Martín, M.; Pollán, M. Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype. Nutrients 2020, 12, 3132.

AMA Style

Lope V, Guerrero-Zotano Á, Casas A, Baena-Cañada JM, Bermejo B, Pérez-Gómez B, Criado-Navarro I, Antolín S, Sánchez-Rovira P, Ramos-Vázquez M, Antón A, Castelló A, García-Saénz JÁ, Muñoz M, de Juan A, Andrés R, Llombart-Cussac A, Hernando B, Franquesa RM, Caballero R, Priego-Capote F, Martín M, Pollán M. Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype. Nutrients. 2020; 12(10):3132.

Chicago/Turabian Style

Lope, Virginia; Guerrero-Zotano, Ángel; Casas, Ana; Baena-Cañada, José M.; Bermejo, Begoña; Pérez-Gómez, Beatriz; Criado-Navarro, Inmaculada; Antolín, Silvia; Sánchez-Rovira, Pedro; Ramos-Vázquez, Manuel; Antón, Antonio; Castelló, Adela; García-Saénz, José Á.; Muñoz, Montserrat; de Juan, Ana; Andrés, Raquel; Llombart-Cussac, Antonio; Hernando, Blanca; Franquesa, Rosa M.; Caballero, Rosalia; Priego-Capote, Feliciano; Martín, Miguel; Pollán, Marina. 2020. "Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype" Nutrients 12, no. 10: 3132.

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