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Article

Physiologic Effects of Exogenous Dextrose in Murine Klebsiella pneumoniae Sepsis Vary by Route of Provision

1
Division of Pulmonary, Allergy, Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
2
Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, PA 15261, USA
3
Center for Medicine and the Microbiome, University of Pittsburgh, Pittsburgh, PA 15261, USA
4
VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(10), 2901; https://doi.org/10.3390/nu12102901
Received: 5 September 2020 / Revised: 18 September 2020 / Accepted: 20 September 2020 / Published: 23 September 2020
(This article belongs to the Special Issue Influence of Carbohydrates Intake on Inflammation)
Sepsis is characterized by a dysregulated immune response to infection. Nutrition is important in the care of septic patients, but the effects of specific nutrients on inflammation in sepsis are not well defined. Our prior work has shown benefits from early enteral dextrose infusion in a preclinical endotoxemia model of sepsis. In the current study, we extend our initial work to examine the effects of dextrose infusions, varying by route of administration, on inflammation and glycemic control in a more clinically relevant and translational model of Klebsiella pneumoniae (KP) bacteremia. Ten-week old C57BL6/J male mice (n = 31) underwent the implantation of indwelling vascular catheters, followed by inoculation with oropharyngeal KP. The mice were randomized 24 h after inoculation to (1) intravenous (IV) dextrose, (2) enteral dextrose, or (3) enteral saline (control) to study the effects on systemic inflammation, hemodynamics, and glycemic control. At 72 h, 77% of the control mice died, whereas IV dextrose induced 100% mortality, associated with increased inflammation, hyperglycemia, and hypotension. Enteral dextrose reduced mortality to 27%, promoted euglycemia, and reduced inflammation compared to IV dextrose. We conclude, in a bacteremic model of sepsis, that enteral (but not IV) dextrose administration is protective, suggesting that the route of nutrient support influences inflammation in sepsis. View Full-Text
Keywords: carbohydrate; inflammation; sepsis; pneumonia; hyperglycemia carbohydrate; inflammation; sepsis; pneumonia; hyperglycemia
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MDPI and ACS Style

Chuan, B.; Guo, L.; Cooper, B.; Rawal, S.; Gallego-Martin, T.; Zhang, Y.; McVerry, B.J.; O’Donnell, C.P.; Shah, F.A. Physiologic Effects of Exogenous Dextrose in Murine Klebsiella pneumoniae Sepsis Vary by Route of Provision. Nutrients 2020, 12, 2901. https://doi.org/10.3390/nu12102901

AMA Style

Chuan B, Guo L, Cooper B, Rawal S, Gallego-Martin T, Zhang Y, McVerry BJ, O’Donnell CP, Shah FA. Physiologic Effects of Exogenous Dextrose in Murine Klebsiella pneumoniae Sepsis Vary by Route of Provision. Nutrients. 2020; 12(10):2901. https://doi.org/10.3390/nu12102901

Chicago/Turabian Style

Chuan, Byron, Lanping Guo, Bryce Cooper, Sagar Rawal, Teresa Gallego-Martin, Yingze Zhang, Bryan J. McVerry, Christopher P. O’Donnell, and Faraaz Ali Shah. 2020. "Physiologic Effects of Exogenous Dextrose in Murine Klebsiella pneumoniae Sepsis Vary by Route of Provision" Nutrients 12, no. 10: 2901. https://doi.org/10.3390/nu12102901

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