Associations between Dietary Patterns and Bile Acids—Results from a Cross-Sectional Study in Vegans and Omnivores

Trefflich, Iris; Marschall, Hanns-Ulrich; Giuseppe, Romina di; Ståhlman, Marcus; Michalsen, Andreas; Lampen, Alfonso; Abraham, Klaus; Weikert, Cornelia

doi:10.3390/nu12010047

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Associations between Dietary Patterns and Bile Acids—Results from a Cross-Sectional Study in Vegans and Omnivores

Iris Trefflich

^1,2,*

Hanns-Ulrich Marschall

⁴,

²,

¹,

and

^1,2

Department of Food Safety, German Federal Institute for Risk Assessment, 10589 Berlin, Germany

Institute for Social Medicine, Epidemiology and Health Economics, Charité-University Medicine, 10589 Berlin, Germany

Department of Molecular and Clinical Medicine/Wallenberg Laboratory, University of Gothenburg, 405 30 Gothenburg, Sweden

⁴

Institute for Epidemiology, University Kiel, 24105 Kiel, Germany

Author to whom correspondence should be addressed.

Nutrients 2020, 12(1), 47; https://doi.org/10.3390/nu12010047

Received: 22 November 2019 / Revised: 13 December 2019 / Accepted: 19 December 2019 / Published: 23 December 2019

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Abstract

Bile acids play an active role in fat metabolism and, in high-fat diets, elevated concentrations of fecal bile acids may be related to an increased risk of colorectal cancer. This study investigated concentrations of fecal and serum bile acids in 36 vegans and 36 omnivores. The reduced rank regression was used to identify dietary patterns associated with fecal bile acids. Dietary patterns were derived with secondary and conjugated fecal bile acids as response variables and 53 food groups as predictors. Vegans had higher fiber (p < 0.01) and lower fat (p = 0.0024) intake than omnivores. In serum, primary and glycine-conjugated bile acids were higher in vegans than in omnivores (p ≤ 0.01). All fecal bile acids were significantly lower in vegans compared to omnivores (p < 0.01). Processed meat, fried potatoes, fish, margarine, and coffee contributed most positively, whereas muesli most negatively to a dietary pattern that was directly associated with all fecal bile acids. According to the pattern, fat intake was positively and fiber intake was inversely correlated with bile acids. The findings contribute to the evidence that, in particular, animal products and fat may play a part in higher levels of fecal bile acids. View Full-Text

Keywords: vegan diet; fecal and serum bile acids; dietary pattern; reduced rank regression

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Trefflich, I.; Marschall, H.-U.; Giuseppe, R.d.; Ståhlman, M.; Michalsen, A.; Lampen, A.; Abraham, K.; Weikert, C. Associations between Dietary Patterns and Bile Acids—Results from a Cross-Sectional Study in Vegans and Omnivores. Nutrients 2020, 12, 47. https://doi.org/10.3390/nu12010047

AMA Style

Trefflich I, Marschall H-U, Giuseppe Rd, Ståhlman M, Michalsen A, Lampen A, Abraham K, Weikert C. Associations between Dietary Patterns and Bile Acids—Results from a Cross-Sectional Study in Vegans and Omnivores. Nutrients. 2020; 12(1):47. https://doi.org/10.3390/nu12010047

Chicago/Turabian Style

Trefflich, Iris, Hanns-Ulrich Marschall, Romina d. Giuseppe, Marcus Ståhlman, Andreas Michalsen, Alfonso Lampen, Klaus Abraham, and Cornelia Weikert. 2020. "Associations between Dietary Patterns and Bile Acids—Results from a Cross-Sectional Study in Vegans and Omnivores" Nutrients 12, no. 1: 47. https://doi.org/10.3390/nu12010047

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Associations between Dietary Patterns and Bile Acids—Results from a Cross-Sectional Study in Vegans and Omnivores

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