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Open AccessArticle

Maternal Selenium Deficiency in Mice Alters Offspring Glucose Metabolism and Thyroid Status in a Sexually Dimorphic Manner

1
School of Medical Science, Menzies Health Institute Queensland, Griffith University Gold, Coast Campus, Southport, QLD 4215, Australia
2
The School of Biomedical Sciences, The University of Queensland, St Lucia, QLD 4072, Australia
*
Author to whom correspondence should be addressed.
indicates authors contributes equally.
Nutrients 2020, 12(1), 267; https://doi.org/10.3390/nu12010267
Received: 3 January 2020 / Revised: 16 January 2020 / Accepted: 19 January 2020 / Published: 20 January 2020
(This article belongs to the Special Issue Diet, Nutrition and Fetal Programming)
Selenium is an essential micronutrient commonly deficient in human populations. Selenium deficiency increases the risks of pregnancy complications; however, the long-term impact of selenium deficiency on offspring disease remains unclear. This study investigates the effects of selenium deficiency during pregnancy on offspring metabolic function. Female C57BL/6 mice were allocated to control (>190 μg selenium/kg, n = 8) or low selenium (<50 μg selenium/kg, n = 8) diets prior to mating and throughout gestation. At postnatal day (PN) 170, mice underwent an intraperitoneal glucose tolerance test and were culled at PN180 for biochemical analysis. Mice exposed to selenium deficiency in utero had reduced fasting blood glucose but increased postprandial blood glucose concentrations. Male offspring from selenium-deficient litters had increased plasma insulin levels in conjunction with reduced plasma thyroxine (tetraiodothyronine or T4) concentrations. Conversely, females exposed to selenium deficiency in utero exhibited increased plasma thyroxine levels with no change in plasma insulin. This study demonstrates the importance of adequate selenium intake around pregnancy for offspring metabolic health. Given the increasing prevalence of metabolic disease, this study highlights the need for appropriate micronutrient intake during pregnancy to ensure a healthy start to life. View Full-Text
Keywords: DOHaD; micronutrients; pregnancy; reproduction; selenoprotein; endocrine DOHaD; micronutrients; pregnancy; reproduction; selenoprotein; endocrine
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Hofstee, P.; McKeating, D.R.; Bartho, L.A.; Anderson, S.T.; Perkins, A.V.; Cuffe, J.S.M. Maternal Selenium Deficiency in Mice Alters Offspring Glucose Metabolism and Thyroid Status in a Sexually Dimorphic Manner. Nutrients 2020, 12, 267.

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