Identification of a Circulating Amino Acid Signature in Frail Older Persons with Type 2 Diabetes Mellitus: Results from the Metabofrail Study
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Blood Collection and Determination of Serum Concentrations of Amino Acids and Derivatives
2.3. Statistical Analysis
2.4. Partial Least Squares-Discriminant Analysis and Double Cross-Validation Procedures
3. Results
3.1. Study Population
3.2. Identification of Circulating Amino Acid Profiles
4. Discussion
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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F-T2DM (n = 66) | Controls (n = 30) | p | |
---|---|---|---|
Age, years (mean ± SD) | 76.5 ± 14.5 | 74.6 ± 4.3 | 0.46 |
Sex (female), n (%) | 32 (48) | 16 (53) | 0.82 |
BMI, kg/m2 (mean ± SD) | 29.2 ± 4.9 | 26.7 ± 2.4 | 0.01 |
SPPB score (mean ± SD) | 8.6 ± 2.9 | 11.3 ± 0.9 | <0.0001 |
Number of diseases (mean ± SD) § | 2.8 ± 1.0 | 2.9 ± 2.0 | 0.86 |
Analytes | F-T2DM (n = 66) | Controls (n = 30) |
---|---|---|
3-methylhistidine | 7.8 ± 4.2 | 5.2 ± 2.5 |
Alanine | 542.3 ± 165.8 | 384.3 ± 98.3 |
Arginine | 168.3 ± 91.2 | 103.7 ± 31.2 |
Ethanolamine | 11.5 ± 3.4 | 9.0 ± 2.2 |
Glutamic acid | 130.0 ± 66.8 | 54.3 ± 21.3 |
Ornithine | 103.2 ± 37.6 | 109.4 ± 25.0 |
Sarcosine | 2.5 ± 0.9 | 1.6 ± 0.6 |
Taurine | 100.4 ± 49.0 | 189.5 ± 47.2 |
Tryptophan | 66.2 ± 23.4 | 62.0 ± 13.1 |
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Calvani, R.; Rodriguez-Mañas, L.; Picca, A.; Marini, F.; Biancolillo, A.; Laosa, O.; Pedraza, L.; Gervasoni, J.; Primiano, A.; Conta, G.; et al. Identification of a Circulating Amino Acid Signature in Frail Older Persons with Type 2 Diabetes Mellitus: Results from the Metabofrail Study. Nutrients 2020, 12, 199. https://doi.org/10.3390/nu12010199
Calvani R, Rodriguez-Mañas L, Picca A, Marini F, Biancolillo A, Laosa O, Pedraza L, Gervasoni J, Primiano A, Conta G, et al. Identification of a Circulating Amino Acid Signature in Frail Older Persons with Type 2 Diabetes Mellitus: Results from the Metabofrail Study. Nutrients. 2020; 12(1):199. https://doi.org/10.3390/nu12010199
Chicago/Turabian StyleCalvani, Riccardo, Leocadio Rodriguez-Mañas, Anna Picca, Federico Marini, Alessandra Biancolillo, Olga Laosa, Laura Pedraza, Jacopo Gervasoni, Aniello Primiano, Giorgia Conta, and et al. 2020. "Identification of a Circulating Amino Acid Signature in Frail Older Persons with Type 2 Diabetes Mellitus: Results from the Metabofrail Study" Nutrients 12, no. 1: 199. https://doi.org/10.3390/nu12010199
APA StyleCalvani, R., Rodriguez-Mañas, L., Picca, A., Marini, F., Biancolillo, A., Laosa, O., Pedraza, L., Gervasoni, J., Primiano, A., Conta, G., Bourdel-Marchasson, I., Regueme, S. C., Bernabei, R., Marzetti, E., Sinclair, A. J., & Gambassi, G., on behalf of the European MID-Frail Consortium. (2020). Identification of a Circulating Amino Acid Signature in Frail Older Persons with Type 2 Diabetes Mellitus: Results from the Metabofrail Study. Nutrients, 12(1), 199. https://doi.org/10.3390/nu12010199