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Effect of Cdx2 Polymorphism on the Relationship between Dietary Calcium Intake and Peak Bone Mass in Young Japanese Women

1
Department of Nutrition and Food Science, Graduate School of Humanities and Sciences, Ochanomizu University, Tokyo 112-8610, Japan
2
Laboratory of Nutrition Physiology, Tokyo Kasei University, Tokyo 173-8602, Japan
3
Institute for Human Life Innovation, Ochanomizu University, Tokyo 112-8610, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2020, 12(1), 191; https://doi.org/10.3390/nu12010191
Received: 6 December 2019 / Revised: 6 January 2020 / Accepted: 8 January 2020 / Published: 10 January 2020
(This article belongs to the Section Nutrigenetics and Nutrigenomics)
Studies investigating the effect of the caudal-type homeobox protein 2 (Cdx2) polymorphism in the vitamin D receptor gene and calcium intake on bone mass have shown inconsistent results. This study investigated whether the effect of calcium intake on peak bone mass is affected by Cdx2 polymorphism in young Japanese women. A cross-sectional study of 500 young women was conducted. Dietary intake was assessed by the Food Frequency Questionnaire. The osteo sono-assessment index (OSI), assessed by the qualitative ultrasound method, was used as a bone mass index. The subjects were divided into two groups by the median calcium intake. The OSI was not different among Cdx2 genotypes and between calcium groups (p = 0.960, p = 0.191, respectively). The interaction between calcium and Cdx2 genotypes on the OSI approached significance (GG versus GA and AA genotypes, p = 0.092). The difference in the OSI between calcium groups was significant in the GG genotype (p = 0.028), but not in the GA or AA genotypes (p = 0.501, p = 0.306, respectively). Adjustment for covariates (body mass index and physical activity) did not change the results. In conclusion, the relationship between dietary calcium intake and peak bone mass may vary according to Cdx2 polymorphism. View Full-Text
Keywords: vitamin D receptor gene; Cdx2 polymorphism; bone mass; premenopausal women; calcium consumption vitamin D receptor gene; Cdx2 polymorphism; bone mass; premenopausal women; calcium consumption
MDPI and ACS Style

Oono, F.; Sakamoto, Y.; Tachi, Y.; Mabashi-Asazuma, H.; Iida, K. Effect of Cdx2 Polymorphism on the Relationship between Dietary Calcium Intake and Peak Bone Mass in Young Japanese Women. Nutrients 2020, 12, 191.

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