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NCM 1921, a Mixture of Several Ingredients, Including Fatty Acids and Choline, Attenuates Atopic Dermatitis in 1-Chloro-2,4-Dinitrobenzene-Treated NC/Nga Mice

1
Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Korea
2
Institute of Traditional Medicine & Bioscience, Daejeon University, Daejeon 34520, Korea
3
Department of Acupuncture and Moxibustion, Won-Kwang University Korean Medicine Hospital, Deokjin-gu, Jeonju-si, Jeollabuk-do 54538, Korea
4
Sunseo Omega3, 53 Judeognong-gong-gil, Chungju-si, Chungcheongbuk-do 27462, Korea
5
Department of Herbology, College of Korean Medicine, Sangji University, Wonju 26339, Korea
6
Department of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, Won-Kwang University Korean Medicine Hospital 895 Muwang-ro, Iksan-si, Jeollabuk-do 54538, Korea
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(1), 165; https://doi.org/10.3390/nu12010165
Received: 24 November 2019 / Revised: 28 December 2019 / Accepted: 3 January 2020 / Published: 7 January 2020
(This article belongs to the Section Nutritional Immunology)
Atopic dermatitis (AD) is a chronic inflammatory skin disease in humans. In this study, we evaluated the effects of a mixture (NCM 1921) of omega-3 butter, omega-3 beef tallow oil, omega-3 lard oil, caprylic acid, lauric acid, choline, and Fe on AD in 1-chloro-2,4-dinitrobenzene (DNCB)-treated NC/Nga mice. NCM 1921 significantly ameliorated the macroscopic and microscopic signs and reduced skin thickness and mast cell incorporation in the skin lesions of mice with DNCB-induced AD. Furthermore, it reduced serum immunoglobulin E levels; reduced the number of IgE-producing B cells, peripheral blood mononuclear cells, white blood cells, and differential white blood cells; and increased the number of lymphocytes. NCM 1921 normalized the total cell number in dorsal skin tissue, the axillary lymph node, and spleen following DNCB exposure and reduced the number of CD23+/B220+ cells in the axillary lymph node and CD3+ cells in dorsal skin tissue. Moreover, it reduced the levels of interleukin (IL)-4 and IL-13 but increased the levels of interferon-γ in anti-CD3–stimulated splenocytes. Immunohistofluorescence staining showed that NCM 1921 treatment significantly increased claudin1, filaggrin, and Sirt1 protein expressions in AD skin lesions. These results suggest that NCM 1921 could be a valuable remedy for the treatment of AD.
Keywords: atopic dermatitis; immune cells; inflammatory cytokine; skin barrier; fatty acid mixture atopic dermatitis; immune cells; inflammatory cytokine; skin barrier; fatty acid mixture
MDPI and ACS Style

Lee, Y.-S.; Yang, W.-K.; Jo, E.-H.; Shin, S.H.; Lee, Y.-C.; Park, M.-C.; Kim, S.-H. NCM 1921, a Mixture of Several Ingredients, Including Fatty Acids and Choline, Attenuates Atopic Dermatitis in 1-Chloro-2,4-Dinitrobenzene-Treated NC/Nga Mice. Nutrients 2020, 12, 165.

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