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The Effect of Zinc, Selenium, and Their Combined Supplementation on Androgen Receptor Protein Expression in the Prostate Lobes and Serum Steroid Hormone Concentrations of Wistar Rats

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Department of Toxicology, Medical University of Lodz, Muszyńskiego 1, 90-151 Lodz, Poland
2
Department of Nephropathology, Medical University of Lodz, Pomorska 251, 92-213 Lodz, Poland
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(1), 153; https://doi.org/10.3390/nu12010153
Received: 12 December 2019 / Revised: 29 December 2019 / Accepted: 4 January 2020 / Published: 6 January 2020
Background: Zinc (Zn) and selenium (Se) play a well-documented role in cancer prevention (e.g., for prostate cancer), and their combined supplementation is often given as a recommended prophylactic agent. The aim of the study was to determine the influence of Zn and/or Se supplementation on the androgen receptor (AR) in the prostate lobes and the serum selected hormone concentrations; a hitherto unresearched topic. Methods: Male rats (n = 84) were administered with Zn and/or Se intragastrically for up to 90 days. The effects of administration on the tested parameters were checked after 30 and 90 days of administration and additionally, 90 days after the end of 90 day administration. Results: Zn alone leads to an increase in serum testosterone concentrations, while the protein expression of AR in both parts of the prostate increases. Combined administration of Zn and Se eliminates the effect of Zn, which may suggest that these two elements act antagonistically. Se supplementation alone results in the same level of AR protein expression in administration and 90 days after administration periods. Conclusion: This paper presents the first report of the influence of Zn and/or Se supplementation on the protein expression of AR in the prostate. Our findings seem to indicate that simultaneous supplementation of both elements may be ineffective. View Full-Text
Keywords: rat; prostate; zinc; selenium; supplementation; androgen receptor; hormones rat; prostate; zinc; selenium; supplementation; androgen receptor; hormones
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Daragó, A.; Klimczak, M.; Stragierowicz, J.; Stasikowska-Kanicka, O.; Kilanowicz, A. The Effect of Zinc, Selenium, and Their Combined Supplementation on Androgen Receptor Protein Expression in the Prostate Lobes and Serum Steroid Hormone Concentrations of Wistar Rats. Nutrients 2020, 12, 153.

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