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Article

Expression of Renin-Angiotensin System Components in the Taste Organ of Mice

1
Section of Oral Neuroscience, Graduate School of Dental Sciences, Kyushu University, 3–1–1 Maidashi, Higashi-ku, Fukuoka 812–8582, Japan
2
Division of Sensory Physiology, Development Center for Five-Sense Devices, Kyushu University, Fukuoka 819-0395, Japan
3
Section of Orthodontics and Dentofacial Orthopedics, Division of Oral Health, Growth, and Development, Faculty of Dental Science, Kyushu University, Fukuoka 812–8582, Japan
4
Department of Oral Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, Japan
5
Monell Chemical Senses Center, Philadelphia, PA 19104, USA
*
Authors to whom correspondence should be addressed.
Nutrients 2019, 11(9), 2251; https://doi.org/10.3390/nu11092251
Received: 2 September 2019 / Revised: 13 September 2019 / Accepted: 15 September 2019 / Published: 19 September 2019
(This article belongs to the Special Issue Salt Taste, Nutrition, and Health)
The systemic renin-angiotensin system (RAS) is an important regulator of body fluid and sodium homeostasis. Angiotensin II (AngII) is a key active product of the RAS. We previously revealed that circulating AngII suppresses amiloride-sensitive salt taste responses and enhances the responses to sweet compounds via the AngII type 1 receptor (AT1) expressed in taste cells. However, the molecular mechanisms underlying the modulation of taste function by AngII remain uncharacterized. Here we examined the expression of three RAS components, namely renin, angiotensinogen, and angiotensin-converting enzyme-1 (ACE1), in mouse taste tissues. We found that all three RAS components were present in the taste buds of fungiform and circumvallate papillae and co-expressed with αENaC (epithelial sodium channel α-subunit, a salt taste receptor) or T1R3 (taste receptor type 1 member 3, a sweet taste receptor component). Water-deprived mice exhibited significantly increased levels of renin expression in taste cells (p < 0.05). These results indicate the existence of a local RAS in the taste organ and suggest that taste function may be regulated by both locally-produced and circulating AngII. Such integrated modulation of peripheral taste sensitivity by AngII may play an important role in sodium/calorie homeostasis. View Full-Text
Keywords: taste; sodium taste; renin; angiotensin II; angiotensinogen; angiotensin-converting enzyme taste; sodium taste; renin; angiotensin II; angiotensinogen; angiotensin-converting enzyme
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MDPI and ACS Style

Shigemura, N.; Takai, S.; Hirose, F.; Yoshida, R.; Sanematsu, K.; Ninomiya, Y. Expression of Renin-Angiotensin System Components in the Taste Organ of Mice. Nutrients 2019, 11, 2251. https://doi.org/10.3390/nu11092251

AMA Style

Shigemura N, Takai S, Hirose F, Yoshida R, Sanematsu K, Ninomiya Y. Expression of Renin-Angiotensin System Components in the Taste Organ of Mice. Nutrients. 2019; 11(9):2251. https://doi.org/10.3390/nu11092251

Chicago/Turabian Style

Shigemura, Noriatsu, Shingo Takai, Fumie Hirose, Ryusuke Yoshida, Keisuke Sanematsu, and Yuzo Ninomiya. 2019. "Expression of Renin-Angiotensin System Components in the Taste Organ of Mice" Nutrients 11, no. 9: 2251. https://doi.org/10.3390/nu11092251

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