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Plant Bioactives and the Prevention of Prostate Cancer: Evidence from Human Studies

Quadram Institute Bioscience, Norwich Research Park, Norwich, Norfolk NR4 7UQ, UK
Urology Department, Norfolk and Norwich University Hospital, Colney Lane Norwich NR4 7UY, UK
The Liggins Institute, University of Auckland, 84 Park Road, Grafton, Auckland 92019, New Zealand
Author to whom correspondence should be addressed.
Joint 1st author.
Nutrients 2019, 11(9), 2245;
Received: 1 August 2019 / Revised: 6 September 2019 / Accepted: 10 September 2019 / Published: 18 September 2019
Prostate cancer has become the most common form of non-cutaneous (internal) malignancy in men, accounting for 26% of all new male visceral cancer cases in the UK. The aetiology and pathogenesis of prostate cancer are not understood, but given the age-adjusted geographical variations in prostate cancer incidence quoted in epidemiological studies, there is increasing interest in nutrition as a relevant factor. In particular, foods rich in phytochemicals have been proposed to reduce the risk of prostate cancer. Epidemiological studies have reported evidence that plant-based foods including cruciferous vegetables, garlic, tomatoes, pomegranate and green tea are associated with a significant reduction in the progression of prostate cancer. However, while there is well-documented mechanistic evidence at a cellular level of the manner by which individual dietary components may reduce the risk of prostate cancer or its progression, evidence from intervention studies is limited. Moreover, clinical trials investigating the link between the dietary bioactives found in these foods and prostate cancer have reported varied conclusions. Herein, we review the plant bioactives for which there is substantial evidence from epidemiological and human intervention studies. The aim of this review is to provide important insights into how particular plant bioactives (e.g., sulfur-containing compounds, carotenoids and polyphenols) present in commonly consumed food groups may influence the development and progression of prostate cancer. View Full-Text
Keywords: nutrition; bioactives; phytochemicals; prostate cancer nutrition; bioactives; phytochemicals; prostate cancer
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MDPI and ACS Style

Livingstone, T.L.; Beasy, G.; Mills, R.D.; Plumb, J.; Needs, P.W.; Mithen, R.; Traka, M.H. Plant Bioactives and the Prevention of Prostate Cancer: Evidence from Human Studies. Nutrients 2019, 11, 2245.

AMA Style

Livingstone TL, Beasy G, Mills RD, Plumb J, Needs PW, Mithen R, Traka MH. Plant Bioactives and the Prevention of Prostate Cancer: Evidence from Human Studies. Nutrients. 2019; 11(9):2245.

Chicago/Turabian Style

Livingstone, Tracey L., Gemma Beasy, Robert D. Mills, Jenny Plumb, Paul W. Needs, Richard Mithen, and Maria H. Traka 2019. "Plant Bioactives and the Prevention of Prostate Cancer: Evidence from Human Studies" Nutrients 11, no. 9: 2245.

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