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Anti-Obesity Effects of the Flower of Prunus persica in High-Fat Diet-Induced Obese Mice

1
Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea
2
Korea Institute of Science and Technology for Eastern Medicine (KISTEM), NeuMed Inc., 88 Imun-ro, Dongdaemun-gu, Seoul 02440, Korea
3
Department of Herbal Pharmacology, College of Korean Medicine, Gachon University, 1342 Seongnamdae-ro, Sujeong-gu, Seongnam-si, Gyeonggi-do 13120, Korea
*
Authors to whom correspondence should be addressed.
The two authors contributed equally.
Nutrients 2019, 11(9), 2176; https://doi.org/10.3390/nu11092176
Received: 15 August 2019 / Revised: 29 August 2019 / Accepted: 2 September 2019 / Published: 11 September 2019
Prunus persica (L.) Batsch is a deciduous fruit tree cultivated worldwide. The flower of P. persica (PPF), commonly called the peach blossom, is currently consumed as a tea for weight loss in East Asia; however, its anti-obesity effects have yet to be demonstrated in vitro or in vivo. Since PPF is rich in phytochemicals with anti-obesity properties, we aimed to investigate the effects of PPF on obesity and its underlying mechanism using a diet-induced obesity model. Male C57BL/6 mice were fed either normal diet, high-fat diet (HFD), or HFD containing 0.2% or 0.6% PPF water extract for 8 weeks. PPF significantly reduced body weight, abdominal fat mass, serum glucose, alanine transaminase and aspartate aminotransferase levels, and liver and spleen weights compared to the HFD control group. Real-time quantitative polymerase chain reaction analysis revealed that PPF suppressed lipogenic gene expression, including stearoyl-CoA desaturase-1 and -2 and fatty acid synthase, and up-regulated the fatty acid β-oxidation gene, carnitine palmitoyltransferase-1, in the liver. Our results suggest that PPF exerts anti-obesity effects in obese mice and these beneficial effects might be mediated through improved hepatic lipid metabolism by reducing lipogenesis and increasing fatty acid oxidation. View Full-Text
Keywords: Prunus persica; peach blossom; high-fat diet; anti-obesity; glucose; liver; lipogenesis; β-oxidation Prunus persica; peach blossom; high-fat diet; anti-obesity; glucose; liver; lipogenesis; β-oxidation
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Song, J.; Kim, Y.-S.; Kim, L.; Park, H.J.; Lee, D.; Kim, H. Anti-Obesity Effects of the Flower of Prunus persica in High-Fat Diet-Induced Obese Mice. Nutrients 2019, 11, 2176.

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