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Dietary Curcumin: Correlation between Bioavailability and Health Potential
Review

Potential of Curcumin in Skin Disorders

1
Dermatology Unit, Department of “Medicina dei Sistemi”, University of Rome Tor Vergata, Via Montpellier, 1–00133 Rome, Italy
2
Department of Biology, University of Rome “Tor Vergata”, Via della Ricerca Scientifica, 1–00133 Rome, Italy
3
Microbiology Section, Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier, 1–00133 Rome, Italy
4
Dermatology Unit, Department of Experimental, Diagnostic and Specialty Medicine-DIMES, University of Bologna, Via Massarenti, 1–40138 Bologna, Italy
5
Neurology Unit, Guglielmo de Saliceto Hospital, 29121–29122 Piacenza, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(9), 2169; https://doi.org/10.3390/nu11092169
Received: 11 July 2019 / Revised: 5 August 2019 / Accepted: 15 August 2019 / Published: 10 September 2019
(This article belongs to the Special Issue Dietary Curcumin and Human Health)
Curcumin is a compound isolated from turmeric, a plant known for its medicinal use. Recently, there is a growing interest in the medical community in identifying novel, low-cost, safe molecules that may be used in the treatment of inflammatory and neoplastic diseases. An increasing amount of evidence suggests that curcumin may represent an effective agent in the treatment of several skin conditions. We examined the most relevant in vitro and in vivo studies published to date regarding the use of curcumin in inflammatory, neoplastic, and infectious skin diseases, providing information on its bioavailability and safety profile. Moreover, we performed a computational analysis about curcumin’s interaction towards the major enzymatic targets identified in the literature. Our results suggest that curcumin may represent a low-cost, well-tolerated, effective agent in the treatment of skin diseases. However, bypass of limitations of its in vivo use (low oral bioavailability, metabolism) is essential in order to conduct larger clinical trials that could confirm these observations. The possible use of curcumin in combination with traditional drugs and the formulations of novel delivery systems represent a very promising field for future applicative research. View Full-Text
Keywords: curcumin; antioxidants; molecular docking; inflammatory skin diseases; psoriasis; atopic dermatitis; iatrogenic dermatitis; wound care; skin aging; inflammaging; skin cancer; skin infections curcumin; antioxidants; molecular docking; inflammatory skin diseases; psoriasis; atopic dermatitis; iatrogenic dermatitis; wound care; skin aging; inflammaging; skin cancer; skin infections
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MDPI and ACS Style

Vollono, L.; Falconi, M.; Gaziano, R.; Iacovelli, F.; Dika, E.; Terracciano, C.; Bianchi, L.; Campione, E. Potential of Curcumin in Skin Disorders. Nutrients 2019, 11, 2169. https://doi.org/10.3390/nu11092169

AMA Style

Vollono L, Falconi M, Gaziano R, Iacovelli F, Dika E, Terracciano C, Bianchi L, Campione E. Potential of Curcumin in Skin Disorders. Nutrients. 2019; 11(9):2169. https://doi.org/10.3390/nu11092169

Chicago/Turabian Style

Vollono, Laura; Falconi, Mattia; Gaziano, Roberta; Iacovelli, Federico; Dika, Emi; Terracciano, Chiara; Bianchi, Luca; Campione, Elena. 2019. "Potential of Curcumin in Skin Disorders" Nutrients 11, no. 9: 2169. https://doi.org/10.3390/nu11092169

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