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Open AccessArticle

Worm-Based Alternate Assessment of Probiotic Intervention against Gut Barrier Infection

by Juil Kim 1 and Yuseok Moon 1,2,*
1
Laboratory of Mucosal Exposome and Biomodulation, Department of Biomedical Sciences and Biomedical Research Institute, Pusan National University, Yangsan 50612, Korea
2
College of Information and Biomedical Engineering, Pusan National University, Yangsan 50612, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(9), 2146; https://doi.org/10.3390/nu11092146
Received: 26 July 2019 / Revised: 28 August 2019 / Accepted: 5 September 2019 / Published: 8 September 2019
(This article belongs to the Special Issue Health Benefits of Traditional and Next Generation Probiotics)
The epithelial barrier is the frontline defense against enteropathogenic bacteria and nutrition-linked xenobiotic stressors in the alimentary tract. In particular, enteropathogenic Escherichia coli (EPEC) insults the gut barrier and is increasingly implicated in chronic intestinal diseases such as inflammatory bowel disease. For the efficient development of intervention against barrier-linked distress, the present study provided a Caenorhabditis elegans-based assessment instead of extensive preclinical evaluations using mammalian models. In particular, EPEC infected the gut and shortened the lifespan of C. elegans, which was counteracted by colonization of E. coli strain Nissle 1917 (EcN). In addition to the competitive actions of EcN against EPEC, EcN improved the gut barrier integrity of worms via the Zonula occludens ortholog (Zoo-1) induction, which was verified in the murine infection and colitis model. The worm-based assessment provided a crucial methodology and important insights into the potent chronic events in the human gut barrier after the ingestion of probiotic candidates as a mucoactive dietary or therapeutic agent. View Full-Text
Keywords: gut health; probiotics; Caenorhabditis elegans; epithelial barrier infection gut health; probiotics; Caenorhabditis elegans; epithelial barrier infection
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Kim, J.; Moon, Y. Worm-Based Alternate Assessment of Probiotic Intervention against Gut Barrier Infection. Nutrients 2019, 11, 2146.

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