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Nutrients
Volume 11
Issue 9
10.3390/nu11092049
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Article

Sparassis crispa Intake Improves the Reduced Lipopolysaccharide-Induced TNF-α Production That Occurs upon Exhaustive Exercise in Mice

by
Masataka Uchida
1,
Naoki Horii
1,2,
Natsuki Hasegawa
3,
Eri Oyanagi
4,
Hiromi Yano
4 and
Motoyuki Iemitsu
1,*
1
Faculty of Sport and Health Science, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan
2
Research Fellow of Japan Society for the Promotion of Science, 5-3-1 Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan
3
Research Organization of Science and Technology, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan
4
Department of Health and Sports Science, Kawasaki University of Medical Welfare, Kurashiki, Okayama 701-0193, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(9), 2049; https://doi.org/10.3390/nu11092049
Submission received: 2 August 2019 / Revised: 23 August 2019 / Accepted: 25 August 2019 / Published: 2 September 2019
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Abstract

Our previous study showed that lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α production is inhibited by acute exhaustive exercise in mice, leading to transient immunodepression after exercise. Sparassis crispa (SC), an edible mushroom, has immunopotentiative properties. This study aimed to clarify the effects of SC intake on reduced LPS-induced TNF-α production upon exhaustive exercise in mice. Male C3H/HeN mice were randomly divided into three groups: normal chow intake + resting sedentary, normal chow intake + acute exhaustive treadmill running exercise, and SC intake (chow containing 5% SC powder for 8 weeks) + the exhaustive exercise groups. Each group was injected with LPS immediately after the exhaustive exercise or rest. Plasma and tissue TNF-α levels were significantly decreased by exhaustive exercise. However, this reduction of the TNF-α level was partially attenuated in the plasma and small intestine by SC intake. Although levels of TLR4 and MyD88 protein expression were significantly decreased in tissues by exhaustive exercise, the reduction of TLR4 and MyD88 levels in the small intestine was partially attenuated by SC intake. These results suggest that SC intake attenuates exhaustive exercise-induced reduction of TNF-α production via the retention of TLR4 and MyD88 expression in the small intestine.
Keywords: exhaustive exercise; immunodepression; small intestine; toll-like receptor 4 exhaustive exercise; immunodepression; small intestine; toll-like receptor 4

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MDPI and ACS Style

Uchida, M.; Horii, N.; Hasegawa, N.; Oyanagi, E.; Yano, H.; Iemitsu, M. Sparassis crispa Intake Improves the Reduced Lipopolysaccharide-Induced TNF-α Production That Occurs upon Exhaustive Exercise in Mice. Nutrients 2019, 11, 2049. https://doi.org/10.3390/nu11092049

AMA Style

Uchida M, Horii N, Hasegawa N, Oyanagi E, Yano H, Iemitsu M. Sparassis crispa Intake Improves the Reduced Lipopolysaccharide-Induced TNF-α Production That Occurs upon Exhaustive Exercise in Mice. Nutrients. 2019; 11(9):2049. https://doi.org/10.3390/nu11092049

Chicago/Turabian Style

Uchida, Masataka, Naoki Horii, Natsuki Hasegawa, Eri Oyanagi, Hiromi Yano, and Motoyuki Iemitsu. 2019. "Sparassis crispa Intake Improves the Reduced Lipopolysaccharide-Induced TNF-α Production That Occurs upon Exhaustive Exercise in Mice" Nutrients 11, no. 9: 2049. https://doi.org/10.3390/nu11092049

APA Style

Uchida, M., Horii, N., Hasegawa, N., Oyanagi, E., Yano, H., & Iemitsu, M. (2019). Sparassis crispa Intake Improves the Reduced Lipopolysaccharide-Induced TNF-α Production That Occurs upon Exhaustive Exercise in Mice. Nutrients, 11(9), 2049. https://doi.org/10.3390/nu11092049

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