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Open AccessArticle

Impact of Magnesium Supplementation in Muscle Damage of Professional Cyclists Competing in a Stage Race

Department of Biochemistry and Physiology, Faculty of Health of Sciences, University of Valladolid Campus de Soria, 42003 Soria, Spain
Department of Applied Biology-Nutrition and Institute of Bioengineering, Alicante Institute for Health and Biomedical Research (ISABIAL Foundation), 03550 Alicante, Spain
CIBERobn (Fisiopatología de la Obesidad y la Nutrición CB12/03/30038) Instituto de Salud Carlos III, 28029 Madrid, Spain
Department of Anatomy and Radiology, Faculty of Health of Sciences, University of Valladolid, 42004 Soria, Spain
Department of Cell Biology, Histology and Pharmacology, Faculty of Health of Sciences, University of Valladolid, 42004 Soria, Spain
Author to whom correspondence should be addressed.
Nutrients 2019, 11(8), 1927;
Received: 15 July 2019 / Revised: 12 August 2019 / Accepted: 13 August 2019 / Published: 16 August 2019
(This article belongs to the Special Issue Dietary Magnesium for Health and Diseases)
PDF [641 KB, uploaded 16 August 2019]
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Magnesium is a cofactor of different enzymatic reactions involved in anabolic and catabolic processes that affect muscular performance during exercise. In addition, it has been suggested that magnesium could participate in maintaining muscle integrity during demanding effort. The main purpose of this study was to analyze the effects of magnesium supplementation in preventing muscle damage in professional cyclists taking part in a 21-day cycling stage race. Eighteen male professional cyclists (n = 18) from two teams were recruited to participate in the research. They were divided into 2 groups: the control group (n = 9) and the magnesium-supplemented group (n = 9). The supplementation consisted of an intake of 400 mg/day of magnesium during the 3 weeks of competition. Blood samples were collected according to World Anti-Doping Agency rules at three specific moments during competition: immediately before the race; mid competition; and before the last stage. Levels of serum and erythrocyte magnesium, lactate dehydrogenase, creatinine kinase, aspartate transaminase, alanine transaminase, myoglobin, aldolase, total proteins, cortisol and creatinine were determined. Serum and erythrocyte magnesium levels decreased during the race. Circulating tissue markers increased at the end of the race in both groups. However, myoglobin increase was mitigated in the supplemented group compared with the controls. We conclude that magnesium supplementation seems to exert a protective effect on muscle damage. View Full-Text
Keywords: cycling; exercise; muscle damage; performance; supplementation cycling; exercise; muscle damage; performance; supplementation

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Córdova, A.; Mielgo-Ayuso, J.; Roche, E.; Caballero-García, A.; Fernandez-Lázaro, D. Impact of Magnesium Supplementation in Muscle Damage of Professional Cyclists Competing in a Stage Race. Nutrients 2019, 11, 1927.

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