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Uric Acid and Plant-Based Nutrition
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Dietary Antioxidant Supplements and Uric Acid in Chronic Kidney Disease: A Review

1
Division of Nephrology and Hypertension, 1st Department of Internal Medicine, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki 54636, Greece
2
Department of Nephrology, School of Medicine, University of Ioannina, Ioannina 45110, Greece
3
Department of Nephrology, School of Medicine, University of Thessaly, Larissa 41110, Greece
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(8), 1911; https://doi.org/10.3390/nu11081911
Received: 23 July 2019 / Revised: 10 August 2019 / Accepted: 12 August 2019 / Published: 15 August 2019
(This article belongs to the Special Issue Effect of Dietary Intake on Uric Acid)
Increased serum levels of uric acid have been associated with the onset and development of chronic kidney disease (CKD), cardiovascular disease, and mortality, through several molecular pathogenetic mechanisms, such as inflammation and oxidative stress. Oxidative stress is present even in the early stages of CKD, progresses parallelly with the deterioration of kidney function, and is even more exacerbated in end-stage renal disease patients undergoing maintenance hemodialysis. Although acting in the plasma as an antioxidant, once uric acid enters the intracellular environment; it behaves as a powerful pro-oxidant. Exogenous intake of antioxidants has been repeatedly shown to prevent inflammation, atherosclerosis and oxidative stress in CKD patients. Moreover, certain antioxidants have been proposed to exert uric acid-lowering properties. This review aims to present the available data regarding the effects of antioxidant supplements on both oxidative stress and uric acid serum levels, in a population particularly susceptible to oxidative damage such as CKD patients. View Full-Text
Keywords: antioxidants; chronic kidney disease; hyperuricemia; oxidative stress; uric acid antioxidants; chronic kidney disease; hyperuricemia; oxidative stress; uric acid
MDPI and ACS Style

Roumeliotis, S.; Roumeliotis, A.; Dounousi, E.; Eleftheriadis, T.; Liakopoulos, V. Dietary Antioxidant Supplements and Uric Acid in Chronic Kidney Disease: A Review. Nutrients 2019, 11, 1911.

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