Next Article in Journal
Association between Psychosocial Stress and Cardiovascular Disease in Relation to Low Consumption of Fruit and Vegetables in Middle-Aged Men
Previous Article in Journal
Dietary Antioxidant Supplements and Uric Acid in Chronic Kidney Disease: A Review
Open AccessArticle

Associations between Dietary Acid Load and Biomarkers of Inflammation and Hyperglycemia in Breast Cancer Survivors

1
School of Public Health, Division of Epidemiology and Biostatistics, San Diego State University, San Diego, CA 92182-4162 USA
2
Moores Cancer Center, University of California at San Diego, San Diego, CA 92093, USA
3
Department of Pediatrics and Rady Children’s Hospital, University of California at San Diego, San Diego, CA 92093, USA
4
School of Medicine, Department of Pathology, University of California at San Diego, San Diego, CA 92093, USA
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(8), 1913; https://doi.org/10.3390/nu11081913
Received: 28 June 2019 / Revised: 31 July 2019 / Accepted: 9 August 2019 / Published: 15 August 2019
  |  
PDF [235 KB, uploaded 15 August 2019]

Abstract

Metabolic acidosis can lead to inflammation, tissue damage, and cancer metastasis. Dietary acid load contributes to metabolic acidosis if endogenous acid–base balance is not properly regulated. Breast cancer survivors have reduced capacities to adjust their acid–base balance; yet, the associations between dietary acid load and inflammation and hyperglycemia have not been examined among them. We analyzed data collected from 3042 breast cancer survivors enrolled in the Women’s Healthy Eating and Living (WHEL) Study who had provided detailed dietary intakes and measurements of plasma C-reactive protein (CRP) and hemoglobin A1c (HbA1c). Using a cross-sectional design, we found positive associations between dietary acid load and plasma CRP and HbA1c. In the multivariable-adjusted models, compared to women with the lowest quartile, the intakes of dietary acid load among women with the highest quartile showed 30–33% increases of CRP and 6–9% increases of HbA1c. Our study is the first to demonstrate positive associations between dietary acid load and CRP and HbA1c in breast cancer survivors. Our study identifies a novel dietary factor that may lead to inflammation and hyperglycemia, both of which are strong risk factors for breast cancer recurrence and comorbidities. View Full-Text
Keywords: dietary acid load; inflammation; cancer survivors dietary acid load; inflammation; cancer survivors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Wu, T.; Seaver, P.; Lemus, H.; Hollenbach, K.; Wang, E.; Pierce, J.P. Associations between Dietary Acid Load and Biomarkers of Inflammation and Hyperglycemia in Breast Cancer Survivors. Nutrients 2019, 11, 1913.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top