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Protective Effects of Hydrolyzed Chicken Extract (Probeptigen®/Cmi-168) on Memory Retention and Brain Oxidative Stress in Senescence-Accelerated Mice

1
Department of Food and Nutrition, Providence University, Taichung 43301, Taiwan
2
Quanzhou Preschool Education College, Quanzhou 362000, China
3
Scientific Research and Applications, BRAND’S Suntory Asia, Singapore 048423, Singapore
*
Authors to whom correspondence should be addressed.
Nutrients 2019, 11(8), 1870; https://doi.org/10.3390/nu11081870
Received: 17 July 2019 / Revised: 2 August 2019 / Accepted: 6 August 2019 / Published: 12 August 2019
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Abstract

The senescence-accelerated prone (SAMP8) mouse model shows age-dependent deterioration in learning and memory and increased oxidative stress in the brain. We previously showed that healthy subjects on a six-week supplementation of a chicken meat hydrolysate (ProBeptigen®/CMI-168) demonstrated enhanced and sustained cognitive performance up until two weeks after the termination of supplementation. In this study, we investigate the effect of ProBeptigen on the progression of age-related cognitive decline. Three-month old SAMP8 mice were orally administered different doses of ProBeptigen (150,300 or 600 mg/kg/day) or saline daily for 13 weeks. Following ProBeptigen supplementation, mice showed lower scores of senescence and improved learning and memory in avoidance tasks. ProBeptigen treatment also increased antioxidant enzyme activity and dopamine level while reducing protein and lipid peroxidation and mitochondrial DNA damage in the brain. Microarray analysis of hippocampus revealed several processes that may be involved in the improvement of cognitive ability by ProBeptigen, including heme binding, insulin growth factor (IGF) regulation, carboxylic metabolic process, oxidation–reduction process and endopeptidase inhibition. Genes found to be significantly altered in both ProBeptigen treated male and female mice include Mup1, Mup17, Mup21, Ahsg and Alb. Taken together, these results suggest a potential anti-aging effect of ProBeptigen in alleviating cognitive deficits and promoting the antioxidant defense system. View Full-Text
Keywords: SAMP8; memory; chicken meat hydrolysate; antioxidant; hippocampal gene expression; anti-aging SAMP8; memory; chicken meat hydrolysate; antioxidant; hippocampal gene expression; anti-aging
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Chou, M.-Y.; Chen, Y.-J.; Lin, L.-H.; Nakao, Y.; Lim, A.L.; Wang, M.-F.; Yong, S.M. Protective Effects of Hydrolyzed Chicken Extract (Probeptigen®/Cmi-168) on Memory Retention and Brain Oxidative Stress in Senescence-Accelerated Mice. Nutrients 2019, 11, 1870.

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