Next Article in Journal
Bone Protective Effect of Extra-Virgin Olive Oil Phenolic Compounds by Modulating Osteoblast Gene Expression
Next Article in Special Issue
Apo-14´-Carotenoic Acid Is a Novel Endogenous and Bioactive Apo-Carotenoid
Previous Article in Journal
Raw Cow’s Milk Reduces Allergic Symptoms in a Murine Model for Food Allergy—A Potential Role for Epigenetic Modifications
Previous Article in Special Issue
Life after Harvest: Circadian Regulation in Photosynthetic Pigments of Rocket Leaves during Supermarket Storage Affects the Nutritional Quality
Article

Dietary Habits, Fatty Acids and Carotenoid Levels Are Associated with Neovascular Age-Related Macular Degeneration in Chinese

1
Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Sassoon Road, Hong Kong
2
Hong Kong Ophthalmic Associate, Queen’s Road, Hong Kong
3
School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong
4
Department of Vision Informatics, Osaka University, 2-2 Yamadaoka, 565-0871 Osaka, Japan
5
Grantham Hospital, Hospital Authority, Wong Chuk Hang, Hong Kong
6
Department of Ophthalmology, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong
*
Authors to whom correspondence should be addressed.
The authors contributed equally to this work.
Nutrients 2019, 11(8), 1720; https://doi.org/10.3390/nu11081720
Received: 4 July 2019 / Revised: 20 July 2019 / Accepted: 22 July 2019 / Published: 25 July 2019
(This article belongs to the Special Issue Carotenoids in Human Nutrition)
The role of diet and circulatory carotenoids and docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are implicated in age-related macular degeneration (AMD) but not well studied in Chinese. However, other fatty acids were not comprehensively evaluated if it had additional consequence on AMD. This study investigated the relationship among dietary habits, fatty acids levels, carotenoids and AMD in Hong Kong Chinese adults. In this cross-sectional case-controlled study, plasma fatty acids including, saturated fatty acids (SFA), monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), and carotenoids levels were quantified between patients with neovascular AMD (n = 99) and age-gender-matched controls (n = 198). A food frequency questionnaire was also conducted. Low blood carotenoid levels and omega-3 PUFAs namely DHA, EPA and α-linolenic acid increased the odds ratio of developing neovascular AMD. High blood omega-6 PUFAs specifically arachidonic acid and eicosadienoic acid, oleic acid (a MUFA) and SFA levels increased the odds ratio of having neovascular AMD. Neovascular AMD group had significantly less omega-3 PUFA rich food (vegetables, nuts, seafood) intake and higher SFA (meat) intake than controls. In short, neovascular AMD was associated with lower circulatory levels of carotenoids and omega-3 PUFAs, and higher level of omega-6 PUFAs, oleic acid and SFAs in the Hong Kong Chinese population. These findings enhance the understandings of dietary impacts on neovascular AMD and provide a context for future nutritional intervention studies. View Full-Text
Keywords: macular degeneration; polyunsaturated fatty acid; saturated fatty acid; carotenoids macular degeneration; polyunsaturated fatty acid; saturated fatty acid; carotenoids
Show Figures

Figure 1

MDPI and ACS Style

Ng, A.L.-K.; Leung, H.H.; Kawasaki, R.; Ho, W.-L.; Chow, L.L.-W.; Chow, S.S.-W.; Lee, J.C.-Y.; Wong, I.Y.-H. Dietary Habits, Fatty Acids and Carotenoid Levels Are Associated with Neovascular Age-Related Macular Degeneration in Chinese. Nutrients 2019, 11, 1720. https://doi.org/10.3390/nu11081720

AMA Style

Ng AL-K, Leung HH, Kawasaki R, Ho W-L, Chow LL-W, Chow SS-W, Lee JC-Y, Wong IY-H. Dietary Habits, Fatty Acids and Carotenoid Levels Are Associated with Neovascular Age-Related Macular Degeneration in Chinese. Nutrients. 2019; 11(8):1720. https://doi.org/10.3390/nu11081720

Chicago/Turabian Style

Ng, Alex L.-K., Ho H. Leung, Ryo Kawasaki, Wing-Lau Ho, Loraine L.-W. Chow, Sharon S.-W. Chow, Jetty C.-Y. Lee, and Ian Y.-H. Wong 2019. "Dietary Habits, Fatty Acids and Carotenoid Levels Are Associated with Neovascular Age-Related Macular Degeneration in Chinese" Nutrients 11, no. 8: 1720. https://doi.org/10.3390/nu11081720

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop