Next Article in Journal
Lupin Peptide T9 (GQEQSHQDEGVIVR) Modulates the Mutant PCSK9D374Y Pathway: in vitro Characterization of its Dual Hypocholesterolemic Behavior
Previous Article in Journal
Predicting and Testing Bioavailability of Magnesium Supplements
Review

Lipotoxicity in Kidney, Heart, and Skeletal Muscle Dysfunction

1
Division of Nephrology and Endocrinology, the University of Tokyo Graduate School of Medicine, Tokyo 113-8655, Japan
2
Division of CKD Pathophysiology, the University of Tokyo Graduate School of Medicine, Tokyo 113-8655, Japan
*
Author to whom correspondence should be addressed.
These two authors contributed equally to this work.
Nutrients 2019, 11(7), 1664; https://doi.org/10.3390/nu11071664
Received: 3 June 2019 / Revised: 1 July 2019 / Accepted: 17 July 2019 / Published: 20 July 2019
Dyslipidemia is a common nutritional and metabolic disorder in patients with chronic kidney disease. Accumulating evidence supports the hypothesis that prolonged metabolic imbalance of lipids leads to ectopic fat distribution in the peripheral organs (lipotoxicity), including the kidney, heart, and skeletal muscle, which accelerates peripheral inflammation and afflictions. Thus, lipotoxicity may partly explain progression of renal dysfunction and even extrarenal complications, including renal anemia, heart failure, and sarcopenia. Additionally, endoplasmic reticulum stress activated by the unfolded protein response pathway plays a pivotal role in lipotoxicity by modulating the expression of key enzymes in lipid synthesis and oxidation. Here, we review the molecular mechanisms underlying lipid deposition and resultant tissue damage in the kidney, heart, and skeletal muscle, with the goal of illuminating the nutritional aspects of these pathologies. View Full-Text
Keywords: lipotoxicity; kidney; uremia; skeletal muscle; sarcopenia lipotoxicity; kidney; uremia; skeletal muscle; sarcopenia
Show Figures

Graphical abstract

MDPI and ACS Style

Nishi, H.; Higashihara, T.; Inagi, R. Lipotoxicity in Kidney, Heart, and Skeletal Muscle Dysfunction. Nutrients 2019, 11, 1664. https://doi.org/10.3390/nu11071664

AMA Style

Nishi H, Higashihara T, Inagi R. Lipotoxicity in Kidney, Heart, and Skeletal Muscle Dysfunction. Nutrients. 2019; 11(7):1664. https://doi.org/10.3390/nu11071664

Chicago/Turabian Style

Nishi, Hiroshi, Takaaki Higashihara, and Reiko Inagi. 2019. "Lipotoxicity in Kidney, Heart, and Skeletal Muscle Dysfunction" Nutrients 11, no. 7: 1664. https://doi.org/10.3390/nu11071664

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop