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Cardiac Changes in Patients on Long-Term Parenteral Nutrition

Internal Medicine and Clinical Nutrition, Department of Clinical Medicine and Surgery, Federico II University, Via Pansini, 580131 Naples, Italy
Cardiovascular Emergencies and Onco-hematologic Complications, Department of Advanced Biomedical Sciences, Federico II University Medical School, 80131 Naples, Italy
Author to whom correspondence should be addressed.
Nutrients 2019, 11(7), 1587;
Received: 20 June 2019 / Revised: 8 July 2019 / Accepted: 10 July 2019 / Published: 13 July 2019
(This article belongs to the Special Issue Advances of Parenteral Nutrition)
PDF [1073 KB, uploaded 16 July 2019]


Patients with short bowel syndrome (SBS) on long-term home parenteral nutrition (HPN) chronically receive high fluid volumes directly into the right atrium (RA) through the superior vena cava. We retrospectively evaluated cardiac function measured by routine transthoracic echocardiography (TTE) in a population of 26 SBS patients on long-term HPN and compared their data on echocardiograph-derived right heart structure and function, with those of a control group of 26 patients also bearing a central venous catheter (CVC) for other reasons. Results showed that body weight and BMI were significantly higher in the control group. The echocardiographic estimate of RA pressure was higher in HPN patients than in controls (p = 0.01). An increased estimate of RA pressure indicates the need to consider TTE in the follow-up of long-term HPN patients to detect functional impairment early. View Full-Text
Keywords: short bowel syndrome; home parenteral nutrition; transthoracic echocardiography; cardiac changes short bowel syndrome; home parenteral nutrition; transthoracic echocardiography; cardiac changes

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Santarpia, L.; Esposito, R.; Vaccaro, A.; Alfonsi, L.; Pagano, M.C.; Santoro, C.; Marra, M.; Contaldo, F.; Galderisi, M.; Pasanisi, F. Cardiac Changes in Patients on Long-Term Parenteral Nutrition. Nutrients 2019, 11, 1587.

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