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Open AccessArticle

Polyphenols and IUGR Pregnancies: Effects of Maternal Hydroxytyrosol Supplementation on Hepatic Fat Accretion and Energy and Fatty Acids Profile of Fetal Tissues

SGIT-INIA, Ctra. De La Coruña Km. 7,5, 29040-Madrid, Spain
Faculty of Veterinary Medicine, UCM, Ciudad Universitaria s/n, 28040-Madrid, Spain
Department of Physiology and Biochemistry of Animal Nutrition, Estacion Experimental del Zaidin, Spanish National Research Council (CSIC), Cno.del Jueves s/n, Armilla, 18100 Granada, Spain
School of Veterinary Medicine and Zootechnics, Faculty of Agricultural Sciences, University of Cuenca, Avda. Doce de Octubre, 010220 Cuenca, Ecuador
Author to whom correspondence should be addressed.
Nutrients 2019, 11(7), 1534;
Received: 16 June 2019 / Revised: 29 June 2019 / Accepted: 1 July 2019 / Published: 5 July 2019
(This article belongs to the Special Issue Polyphenol-Rich Foods for Human Health and Disease)
PDF [304 KB, uploaded 9 July 2019]


Maternal supplementation with hydroxytyrosol, a polyphenol present in olive leaves and fruits, is a highly promising strategy to improve the oxidative and metabolic status of fetuses at risk of intrauterine growth restriction, which may diminish the appearance of low-birth-weight neonates. The present study aimed to determine whether hydroxytyrosol, by preventing lipid peroxidation, may influence the fat accretion and energy homeostasis in the liver, as well as the fatty acid composition in the liver and muscle. The results indicate that hydroxytyrosol treatment significantly decreased the energy content of the fetal liver, without affecting fat accretion, and caused significant changes in the availability of fatty acids. There were significant increases in the amount of total polyunsaturated fatty acids, omega-3 and omega-6, which are highly important for adequate fetal tissue development. However, there were increases in the omega-6/omega-3 ratio and the desaturation index, which make further studies necessary to determine possible effects on the pro/anti-inflammatory status of the fetuses. View Full-Text
Keywords: antioxidants; intrauterine-growth-restriction; pregnancy; swine-model antioxidants; intrauterine-growth-restriction; pregnancy; swine-model
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Garcia-Contreras, C.; Vazquez-Gomez, M.; Pardo, Z.; Heras-Molina, A.; Pesantez, J.L.; Encinas, T.; Torres-Rovira, L.; Astiz, S.; Nieto, R.; Ovilo, C.; Gonzalez-Bulnes, A.; Isabel, B. Polyphenols and IUGR Pregnancies: Effects of Maternal Hydroxytyrosol Supplementation on Hepatic Fat Accretion and Energy and Fatty Acids Profile of Fetal Tissues. Nutrients 2019, 11, 1534.

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