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Allomyrina dichotoma Larva Extract Ameliorates the Hepatic Insulin Resistance of High-Fat Diet-Induced Diabetic Mice

1
Department of Food and Nutrition, Eulji University, Seongnam 13135, Korea
2
Lee Gil Ya Cancer and Diabetes Institute, Department of molecular medicine, Gachon University, Incheon 21999, Korea
3
Department of Food Technology and Services, Eulji University, Seongnam 13135, Korea
4
College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam 58554, Korea
5
College of Pharmacy, Hanyang University, Ansan 15888, Korea
6
College of Pharmacy and Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Nutrients 2019, 11(7), 1522; https://doi.org/10.3390/nu11071522
Received: 4 June 2019 / Revised: 2 July 2019 / Accepted: 3 July 2019 / Published: 4 July 2019
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Abstract

Allomyrina dichotoma larva is a nutritional-worthy future food resource and it contributes to multiple pharmacological functions. However, its antidiabetic effect and molecular mechanisms are not yet fully understood. Therefore, we investigated the hypolipidemic effect of A. dichotoma larva extract (ADLE) in a high-fat diet (HFD)-induced C57BL/6J mice model. Glucose tolerance and insulin sensitivity in HFD-induced diabetic mice significantly improved after ADLE administration for six weeks. The levels of serum triglyceride (TG), aspartate aminotransferase (AST), alanine transferase (ALT) activity, and lipid accumulation were increased in the liver of HFD-fed mice, but the levels were significantly reduced by the ADLE treatment. Moreover, hepatic fibrosis and inflammatory gene expression in the liver from HFD-treated mice were ameliorated by the ADLE treatment. Dephosphorylation of AMP-activated protein kinase (AMPK) by palmitate was inhibited in the ADLE treated HepG2 cells, and subsequently reduced expression of lipogenic genes, such as SREPBP-1c, ACC, and FAS were observed. The reduced expression of lipogenic genes and an increased phosphorylation of AMPK was also observed in the liver from diabetic mice treated with ADLE. In conclusion, ADLE ameliorates hyperlipidemia through inhibition of hepatic lipogenesis via activating the AMPK signaling pathway. These findings suggest that ADLE and its constituent bioactive compounds are valuable to prevent or treat hepatic insulin resistance in type 2 diabetes. View Full-Text
Keywords: Allomyrina dichotoma larva; hepatic insulin resistance; lipogenesis Allomyrina dichotoma larva; hepatic insulin resistance; lipogenesis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Kim, K.; Bae, G.D.; Lee, M.; Park, E.-Y.; Baek, D.J.; Kim, C.Y.; Jun, H.-S.; Oh, Y.S. Allomyrina dichotoma Larva Extract Ameliorates the Hepatic Insulin Resistance of High-Fat Diet-Induced Diabetic Mice. Nutrients 2019, 11, 1522.

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