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Open AccessArticle

Using the Pleiotropic Characteristics of Curcumin to Validate the Potential Application of a Novel Gene Expression Screening Platform

1
Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan
2
Department of Human Development and Family Studies, National Taiwan Normal University, Taipei 106, Taiwan
3
Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei 112, Taiwan
4
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY 11724, USA
5
Department of Biochemistry, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
6
Graduate Program of Nutrition Science, School of Life Science, National Taiwan Normal University, Taipei 106, Taiwan
*
Authors to whom correspondence should be addressed.
Nutrients 2019, 11(6), 1397; https://doi.org/10.3390/nu11061397
Received: 11 May 2019 / Revised: 12 June 2019 / Accepted: 18 June 2019 / Published: 21 June 2019
(This article belongs to the Special Issue Dietary Bioactives and Human Health)
Curcumin is a polyphenol derived from curcumin longa that exhibits anticancer and anti-inflammatory properties. The consumption of foods at supernutritional levels to obtain health benefits may paradoxically result in negative health outcomes. In the present study, multiple targeting characteristics of curcumin were analyzed using our gene expression screening system, which utilized the gene expression signatures of curcumin from human hepatocellular carcinoma and colorectal cancer cells to query gene expression databases and effectively identify the molecular actions of curcumin. In agreement with prediction, curcumin inhibited NF-κB and Aurora-A, and induced G2/M arrest and apoptosis. Curcumin-suppressed NF-κB was identified through inhibition of PLCG1, PIK3R1, and MALT1 in the CD4-T-cell-receptor-signaling NF-κB cascade pathway. The results suggest that our novel gene expression screening platform is an effective method of rapidly identifying unknown biological functions and side effects of compounds with potential nutraceutical benefits. View Full-Text
Keywords: curcumin; NF-κB; Connectivity map; library of integrated network-based cellular signatures; C-Map and LINCS unified environment; ConsensusPathDB curcumin; NF-κB; Connectivity map; library of integrated network-based cellular signatures; C-Map and LINCS unified environment; ConsensusPathDB
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MDPI and ACS Style

Liao, S.-C.; Hsu, H.-W.; Chuang, K.-L.; Huang, Z.-Y.; Lin, K.-T.; Hsu, W.-H.; Chang, K.-H.; Huang, C.-Y.F.; Su, C.-L. Using the Pleiotropic Characteristics of Curcumin to Validate the Potential Application of a Novel Gene Expression Screening Platform. Nutrients 2019, 11, 1397.

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