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Open AccessArticle

Association of Folate and Vitamins Involved in the 1-Carbon Cycle with Polymorphisms in the Methylenetetrahydrofolate Reductase Gene (MTHFR) and Global DNA Methylation in Patients with Colorectal Cancer

1
Department of Nutrition, Unicesumar, Av. Guedner, 1610, Jardim Aclimação, Maringá, Paraná CEP 87050-900, Brazil
2
Laboratory of Genomics and Molecular Biology, International Research Center, A.C. Camargo Cancer Center, Rua Professor Antônio Prudente, 211, Liberdade, São Paulo, São Paulo CEP 01509-010, Brazil
3
Department of Pelvic Surgery, A.C. Camargo Cancer Center, Rua Professor Antônio Prudente, 211, Liberdade, São Paulo, São Paulo CEP 01509-010, Brazil
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(6), 1368; https://doi.org/10.3390/nu11061368
Received: 29 April 2019 / Revised: 30 May 2019 / Accepted: 4 June 2019 / Published: 18 June 2019
(This article belongs to the Special Issue Nutrition and Cancer: From Prevention to Survivorship)
Folate, vitamin B2, vitamin B6, vitamin B12, choline, and betaine are nutrients involved in the 1-carbon cycle that can alter the levels of DNA methylation and influence genesis and/or tumor progression. Thus, the objective of this study was to evaluate the association of folate and vitamins involved in the 1-carbon cycle and MTHFR polymorphisms in global DNA methylation in patients with colorectal cancer gene. The study included 189 patients with colorectal adenocarcinoma answering a clinical evaluation questionnaire and the Food Frequency Questionnaire (FFQ) validated for patients with colon and rectal cancer. Blood samples were collected for evaluation of MTHFR gene polymorphisms in global DNA methylation in blood and in tumor. The values for serum folate were positively correlated with the equivalent total dietary folate (total DFE) (rho = 0.51, p = 0.03) and global DNA methylation (rho = 0.20, p = 0.03). Individuals aged over 61 years (p = 0.01) in clinicopathological staging III and IV (p = 0.01) and with + heterozygous mutated homozygous genotypes for the MTHFR A1298C gene had higher levels of global DNA methylation (p = 0.04). The association between dietary intake of folate, serum folate, and tumor stage were predictive of global DNA methylation in patients’ blood. The levels of serum folate, the dietary folate and the status of DNA methylation can influence clinicopathological staging. View Full-Text
Keywords: folic acid; 1-carbon cycle; DNA methylation; colorectal carcinogenesis folic acid; 1-carbon cycle; DNA methylation; colorectal carcinogenesis
MDPI and ACS Style

Ferrari, A.; Torrezan, G.T.; Carraro, D.M.; Aguiar Junior, S. Association of Folate and Vitamins Involved in the 1-Carbon Cycle with Polymorphisms in the Methylenetetrahydrofolate Reductase Gene (MTHFR) and Global DNA Methylation in Patients with Colorectal Cancer. Nutrients 2019, 11, 1368.

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