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Open AccessArticle

Effect of Postoperative Oral Intake on Prognosis for Esophageal Cancer

1
Department of Health Sciences, Prefectural University of Hiroshima, 1-1-71 Ujina-higashi, Minami-ku, Hiroshima 734-8558, Japan
2
Department of Nutritional Medicine, Graduate School of Human Life Science, Osaka City University, 3-3-138 Sugimoto-cho, Sumiyoshi-ku, Osaka 558-8585, Japan
3
Department of Food and Nutrition, Faculty of Contemporary Human Life Science, Tezukayama University, 3-1-3 Gakuenminami, Nara 631-8585, Japan
4
Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka City University, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
5
Institute of Gastroenterology, Tokyo Women’s Medical University, 8-1 Kawada-cho, Sinjuku-ku, Tokyo 162-8666, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(6), 1338; https://doi.org/10.3390/nu11061338
Received: 15 April 2019 / Revised: 7 June 2019 / Accepted: 12 June 2019 / Published: 14 June 2019
(This article belongs to the Special Issue Nutritional Management of Gastrointestinal Diseases and Disorders)
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Abstract

Background: Patients undergoing surgery for esophageal cancer are at risk of prolonged hospital stay for postoperative malnutrition. Postoperative early oral feeing is a part of the “enhanced recovery after surgery protocol” for coping with this risk. However, the usefulness of early oral intake during perioperatively is questionable. Methods: In total, 117 patients treated surgically for esophageal cancer were analyzed in the study. We assessed the oral energy sufficiency rate per nutritional requirement (oral-E/NR) at the fourth week postoperatively and classified the patients into two groups: Poor oral intake group (POI group; <25% oral-E/NR) and the control group (≥25% oral-E/NR). We analyzed the relationship among postoperative oral intake and prognoses. Results: The POI group had worse postoperative nutritional status and a lower survival rate than the control group. In a multivariate analysis, <25% oral-E/NR was one of the independent factors contributing to negative outcomes postoperatively (adjusted hazard ratio: 2.70, 95% confidence interval: 1.30–5.61). Conclusions: In patients undergoing surgery for esophageal cancer, poor postoperative oral intake negatively affected not only on their postoperative nutritional status but also their overall prognosis. It is necessary to improve the adequacy of oral intake postoperatively for patients with esophageal cancer. View Full-Text
Keywords: esophagectomy; energy intake; nutrition therapy; administration; outcomes research/quality esophagectomy; energy intake; nutrition therapy; administration; outcomes research/quality
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Okada, G.; Momoki, C.; Habu, D.; Kambara, C.; Fujii, T.; Matsuda, Y.; Lee, S.; Osugi, H. Effect of Postoperative Oral Intake on Prognosis for Esophageal Cancer. Nutrients 2019, 11, 1338.

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