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Open AccessArticle

Plasma Trimethylamine-N-oxide following Cessation of L-carnitine Supplementation in Healthy Aged Women

Faculty of Rehabilitation and Kinesiology, Department of Bioenergetics and Nutrition, Gdansk University Physical Education and Sport, Gorskiego 1, 80-336 Gdansk, Poland
Mass Spectrometry Laboratory, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, 02-106 Warsaw, Poland
Author to whom correspondence should be addressed.
Nutrients 2019, 11(6), 1322;
Received: 13 May 2019 / Revised: 31 May 2019 / Accepted: 11 June 2019 / Published: 13 June 2019
(This article belongs to the Special Issue Nutritional Determinants and Cardiovascular Disease)
L-carnitine supplementation elevates plasma trimethylamine-N-oxide (TMAO), which may participate in atherosclerosis development by affecting cholesterol metabolism. The aim of the current study was to determine the effect of increased plasma TMAO on biochemical markers in the blood following cessation of L-carnitine supplementation. The follow-up measurements were performed on subjects who completed 24 weeks of L-carnitine or placebo supplementation protocol. Blood samples were taken after finishing the supplementation and then 4 and 12 months following the supplementation withdrawal. Four months after cessation of L-carnitine supplementation, plasma TMAO concentration reached a normal level which was stable for the following eight months. During this period, no modifications in serum lipid profile and circulating leukocyte count were noted. TMAO implications in health and disease is widely discussed. The results of this study demonstrate no adverse effects of elevated plasma TMAO, induced by L-carnitine, on the measured parameters at 4 and 12 months after withdrawal of supplementation. View Full-Text
Keywords: cardiovascular disease; endothelial dysfunction; atherosclerosis; cholesterol; leukocytes cardiovascular disease; endothelial dysfunction; atherosclerosis; cholesterol; leukocytes
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Samulak, J.J.; Sawicka, A.K.; Samborowska, E.; Olek, R.A. Plasma Trimethylamine-N-oxide following Cessation of L-carnitine Supplementation in Healthy Aged Women. Nutrients 2019, 11, 1322.

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