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Functional Nutrients for Epilepsy

Department of Pharmacology, Department of Biomedicine & Health Sciences, Catholic Neuroscience Institute, Institute of Aging and Metabolic Diseases, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
Author to whom correspondence should be addressed.
Nutrients 2019, 11(6), 1309;
Received: 30 April 2019 / Revised: 5 June 2019 / Accepted: 6 June 2019 / Published: 10 June 2019
PDF [1112 KB, uploaded 13 June 2019]


Epilepsy is a common neurological disorder of which seizures are a core symptom. Approximately one third of epileptic patients are resistant to antiepileptic drugs and therefore require alternative therapeutic options. Dietary and nutritional supplements can in some cases replace drugs, but with the exception of ketogenic diets, there are no officially recommended dietary considerations for patients with epilepsy. In this review we summarize a selection of nutritional suggestions that have proved beneficial in treating different types of epilepsy. We describe the types of seizures and epilepsy and follow this with an introduction to basic molecular mechanisms. We then examine several functional nutrients for which there is clinical evidence of therapeutic efficacy in reducing seizures or epilepsy-associated sudden death. We also discuss experimental results that demonstrate possible molecular mechanisms elicited by the administration of various nutrients. The availability of multiple dietary and nutritional candidates that show favorable outcomes in animals implies that assessing the clinical potential of these substances will improve translational medicine, ultimately benefitting epilepsy patients. View Full-Text
Keywords: epilepsy; seizure; nutrients; omega-3 fatty acid; vitamin D3; vitamin E; vitamin B6 epilepsy; seizure; nutrients; omega-3 fatty acid; vitamin D3; vitamin E; vitamin B6

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Kim, J.-E.; Cho, K.-O. Functional Nutrients for Epilepsy. Nutrients 2019, 11, 1309.

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