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Article

Human Milk Oligosaccharides in the Milk of Mothers Delivering Term versus Preterm Infants

1
Nestlé Research, Vers-Chez-Les-Blanc, 1000 Lausanne, Switzerland
2
Nestle Research Singapore, 29 Quality Road, 618802 Singapore, Singapore
3
Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(6), 1282; https://doi.org/10.3390/nu11061282
Received: 9 May 2019 / Revised: 28 May 2019 / Accepted: 4 June 2019 / Published: 5 June 2019
(This article belongs to the Special Issue Human Milk and Lactation)
Human milk oligosaccharides (HMOs) are a major component of human milk, and play an important role in protecting the infant from infections. Preterm infants are particularly vulnerable, but have improved outcomes if fed with human milk. This study aimed to determine if the HMO composition of preterm milk differed from that of term milk at equivalent stage of lactation and equivalent postmenstrual age. In all, 22 HMOs were analyzed in 500 samples of milk from 25 mothers breastfeeding very preterm infants (< 32 weeks of gestational age, < 1500 g of birthweight) and 28 mothers breastfeeding term infants. The concentrations of most HMOs were comparable at equivalent postpartum age. However, HMOs containing α-1,2-linked fucose were reduced in concentration in preterm milk during the first month of lactation. The concentrations of a number of sialylated oligosaccharides were also different in preterm milk, in particular 3′-sialyllactose concentrations were elevated. At equivalent postmenstrual age, the concentrations of a number of HMOs were significantly different in preterm compared to term milk. The largest differences manifest around 40 weeks of postmenstrual age, when the milk of term infants contains the highest concentrations of HMOs. The observed differences warrant further investigation in view of their potential clinical impact. View Full-Text
Keywords: 2′-fucosyllactose (2′FL); 3′-sialyllactose (3′SL); disialyllacto-N-tetraose (DSLNT); human milk oligosaccharides (HMO); milk group; secretor; Lewis; lactation; preterm 2′-fucosyllactose (2′FL); 3′-sialyllactose (3′SL); disialyllacto-N-tetraose (DSLNT); human milk oligosaccharides (HMO); milk group; secretor; Lewis; lactation; preterm
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MDPI and ACS Style

Austin, S.; De Castro, C.A.; Sprenger, N.; Binia, A.; Affolter, M.; Garcia-Rodenas, C.L.; Beauport, L.; Tolsa, J.-F.; Fumeaux, C.J.F. Human Milk Oligosaccharides in the Milk of Mothers Delivering Term versus Preterm Infants. Nutrients 2019, 11, 1282. https://doi.org/10.3390/nu11061282

AMA Style

Austin S, De Castro CA, Sprenger N, Binia A, Affolter M, Garcia-Rodenas CL, Beauport L, Tolsa J-F, Fumeaux CJF. Human Milk Oligosaccharides in the Milk of Mothers Delivering Term versus Preterm Infants. Nutrients. 2019; 11(6):1282. https://doi.org/10.3390/nu11061282

Chicago/Turabian Style

Austin, Sean, Carlos A. De Castro, Norbert Sprenger, Aristea Binia, Michael Affolter, Clara L. Garcia-Rodenas, Lydie Beauport, Jean-François Tolsa, and Céline J.F. Fumeaux 2019. "Human Milk Oligosaccharides in the Milk of Mothers Delivering Term versus Preterm Infants" Nutrients 11, no. 6: 1282. https://doi.org/10.3390/nu11061282

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