Next Article in Journal
Nutritional Intake, Sports Nutrition Knowledge and Energy Availability in Female Australian Rules Football Players
Previous Article in Journal
Combination of Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Shows a Stronger Anti-Inflammatory Effect than Individual Strains in HT-29 Cells
Open AccessArticle

Olive Leaf Extract (OleaVita) Suppresses Inflammatory Cytokine Production and NLRP3 Inflammasomes in Human Placenta

Laboratory of Animal Reproduction, Department of Animal Science, Tokyo University of Agriculture, Atsugi, Kanagawa 243-0034, Japan
Department of Obstetrics and Gynecology, Jichi Medical University, Shimotsuke, Tochigi 329-0498, Japan
Nutraceuticals Research Office, Nutrition Act Co., Ltd., Ginza, Chuo-ku, Tokyo 104-0061, Japan
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2019, 11(5), 970;
Received: 20 March 2019 / Revised: 19 April 2019 / Accepted: 24 April 2019 / Published: 28 April 2019
The placenta is essential for pregnancy and produces both pro-inflammatory and anti-inflammatory cytokines. Excessive production of inflammatory cytokines, involving interleukin-1β (IL-1β), IL-6, and IL-8, from placental tissues is associated with pregnancy complications. Olive leaf extract has several health benefits, including anti-inflammatory functions. OleaVita is a new commercial olive leaf extract; it is hypothesized to suppress placental inflammation. In human placental tissue culture, OleaVita treatment inhibited the secretion of inflammatory cytokines and NF-κB p65 protein expression. OleaVita also suppressed toll-like receptor ligands-induced IL-1β secretion in human placental tissues. IL-1β is regulated by the NLRP3 inflammasomes, a pivotal regulator of various diseases. OleaVita significantly decreased NLRP3 and pro-IL-1β protein expression, suggesting that it has an inhibitory effect on NLRP3 inflammasome activation. Thus, OleaVita is beneficial as an inhibitor of inflammation and NLRP3 inflammasome activation, and may be used as a supplement for the treatment and prevention of inflammatory diseases. View Full-Text
Keywords: placenta; interleukin; NLRP3 inflammasome; inflammation placenta; interleukin; NLRP3 inflammasome; inflammation
Show Figures

Graphical abstract

MDPI and ACS Style

Kaneko, Y.; Sano, M.; Seno, K.; Oogaki, Y.; Takahashi, H.; Ohkuchi, A.; Yokozawa, M.; Yamauchi, K.; Iwata, H.; Kuwayama, T.; Shirasuna, K. Olive Leaf Extract (OleaVita) Suppresses Inflammatory Cytokine Production and NLRP3 Inflammasomes in Human Placenta. Nutrients 2019, 11, 970.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop