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Open AccessArticle

Effect of Vitamin D3 on the Postprandial Lipid Profile in Obese Patients: A Non-Targeted Lipidomics Study

1
Universitat Rovira i Virgili, Departament de Medicina i Cirurgia, Unitat de Recerca Biomèdica, C/de l’Escorxador S/N, 43003 Tarragona, Spain
2
Campus of International Excellence Southern Catalonia, 43003 Tarragona, Spain
3
Institut d’investigació Sanitària Pere Virgili, C/de l’Escorxador S/N, 43003 Tarragona, Spain
4
Department of Internal Medicine, Center for Diabetes and Vascular Medicine, Franciscus Gasthuis & Vietland, 3045 PM Rotterdam, The Netherlands
5
Department of Clinical Chemistry, Franciscus Gasthuis & Vietland, 3045 PM Rotterdam, The Netherlands
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(5), 1194; https://doi.org/10.3390/nu11051194
Received: 23 April 2019 / Revised: 17 May 2019 / Accepted: 22 May 2019 / Published: 27 May 2019
(This article belongs to the Special Issue Vitamin D and Obesity)
Postprandial lipemia can lead to an accumulation of atherogenic lipoproteins in the circulation associated with systemic low-grade inflammation and an increased risk of cardiovascular disease. Lifestyle and pharmacological treatments are usually prescribed for prevention. Vitamin D3 (cholecalciferol), as an anti-atherogenic agent, is being taken into consideration due to its potential beneficial effects in lipid metabolism and its anti-inflammatory potency. To assess the effects of vitamin D3 in the postprandial lipid profile in obese, vitamin D-deficient women, a non-targeted lipidomics approach using liquid chromatography coupled to a quadrupole time-of flight mass spectrometer was used to identify and quantitate a wide-range of circulating lipid species, including diglycerides, lysophosphatidylcholines, phosphatidylcholines, phosphatidylethanolamines, sphingomyelins and triglycerides. The most important changes were found in plasmatic sphingomyelin levels, which experience a decrease after vitamin D3 intake. Our results suggest a turnover of sphingomyelins, probably due to an increased activity of neutral sphingomyelinases, and, therefore, with implications in the clearance of chylomicrons, LDL and VLDL, decreasing postprandial inflammation and macrophage adherence to endothelia, potentially improving cardiovascular disease risk. View Full-Text
Keywords: cholecalciferol; lipid absorption; lipidomics; obesity; postprandial inflammation; sphingomyelin cholecalciferol; lipid absorption; lipidomics; obesity; postprandial inflammation; sphingomyelin
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Fernández-Arroyo, S.; Hernández-Aguilera, A.; de Vries, M.A.; Burggraaf, B.; van der Zwan, E.; Pouw, N.; Joven, J.; Castro Cabezas, M. Effect of Vitamin D3 on the Postprandial Lipid Profile in Obese Patients: A Non-Targeted Lipidomics Study. Nutrients 2019, 11, 1194.

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