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Dietary and Sentinel Factors Leading to Hemochromatosis

1 and 1,2,3,*
1
Laboratory of Mucosal Exposome and Biomodulation, Department of Biomedical Sciences, Pusan National University, Yangsan 50612, Korea
2
BioMedical Research Institute, Pusan National University, Yangsan 50612, Korea
3
Program of Food Health Sciences, Busan 46241, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(5), 1047; https://doi.org/10.3390/nu11051047
Received: 15 February 2019 / Revised: 29 April 2019 / Accepted: 7 May 2019 / Published: 10 May 2019
(This article belongs to the Special Issue Dietary Trace Minerals)
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PDF [1442 KB, uploaded 10 May 2019]
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Abstract

Although hereditary hemochromatosis is associated with the mutation of genes involved in iron transport and metabolism, secondary hemochromatosis is due to external factors, such as intended or unintended iron overload, hemolysis-linked iron exposure or other stress-impaired iron metabolism. The present review addresses diet-linked etiologies of hemochromatosis and their pathogenesis in the network of genes and nutrients. Although the mechanistic association to diet-linked etiologies can be complicated, the stress sentinels are pivotally involved in the pathological processes of secondary hemochromatosis in response to iron excess and other external stresses. Moreover, the mutations in these sentineling pathway-linked genes increase susceptibility to secondary hemochromatosis. Thus, the crosstalk between nutrients and genes would verify the complex procedures in the clinical outcomes of secondary hemochromatosis and chronic complications, such as malignancy. All of this evidence provides crucial insights into comprehensive clinical or nutritional interventions for hemochromatosis. View Full-Text
Keywords: hemochromatosis; iron transport and metabolism; stress sentinel hemochromatosis; iron transport and metabolism; stress sentinel
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Oh, C.-K.; Moon, Y. Dietary and Sentinel Factors Leading to Hemochromatosis. Nutrients 2019, 11, 1047.

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