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Article

Short-Term High-Starch, Low-Protein Diet Induces Reversible Increase in β-cell Mass Independent of Body Weight Gain in Mice

1
Department of Endocrinology and Metabolism, Fujita Health University, Graduate School of Medicine, Toyoake 470-1192, Japan
2
Departments of Endocrinology and Diabetes, Toyota Memorial Hospital, Toyota 471-8513, Japan
3
Department of Endocrinology, Research Institute of Environmental Medicine, Nagoya University, Nagoya 467-8601 Japan
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(5), 1045; https://doi.org/10.3390/nu11051045
Received: 3 April 2019 / Revised: 8 May 2019 / Accepted: 8 May 2019 / Published: 10 May 2019
(This article belongs to the Special Issue Effects of Dietary Intake on Pancreas)
Long-term exposure to a high starch, low-protein diet (HSTD) induces body weight gain and hyperinsulinemia concomitantly with an increase in β-cell mass (BCM) and pancreatic islets number in mice; however, the effect of short-term exposure to HSTD on BCM and islet number has not been elucidated. In the present study, we investigated changes in body weight, plasma insulin levels, BCM and islet number in mice fed HSTD for 5 weeks followed by normal chow (NC) for 2 weeks. BCM and islet number were increased in mice fed HSTD for 5 weeks compared with those in mice fed NC. On the other hand, mice fed HSTD for 5 weeks followed by NC for 2 weeks (SN) showed decreased BCM and insulin levels, compared to mice fed HSTD for 7 weeks, and no significant differences in these parameters were observed between SN and the control NC at 7 weeks. No significant difference in body weight was observed among HSTD, NC and SN fed groups. These results suggest that a high-starch diet induces an increase in BCM in a manner independent of body weight gain, and that 2 weeks of NC feeding is sufficient for the reversal of the morphological changes induced in islets by HSTD feeding. View Full-Text
Keywords: carbohydrate; β-cell mass; islet number; insulin; dietary intervention carbohydrate; β-cell mass; islet number; insulin; dietary intervention
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MDPI and ACS Style

Masuda, A.; Seino, Y.; Murase, M.; Hidaka, S.; Shibata, M.; Takayanagi, T.; Sugimura, Y.; Hayashi, Y.; Suzuki, A. Short-Term High-Starch, Low-Protein Diet Induces Reversible Increase in β-cell Mass Independent of Body Weight Gain in Mice. Nutrients 2019, 11, 1045. https://doi.org/10.3390/nu11051045

AMA Style

Masuda A, Seino Y, Murase M, Hidaka S, Shibata M, Takayanagi T, Sugimura Y, Hayashi Y, Suzuki A. Short-Term High-Starch, Low-Protein Diet Induces Reversible Increase in β-cell Mass Independent of Body Weight Gain in Mice. Nutrients. 2019; 11(5):1045. https://doi.org/10.3390/nu11051045

Chicago/Turabian Style

Masuda, Atsushi; Seino, Yusuke; Murase, Masatoshi; Hidaka, Shihomi; Shibata, Megumi; Takayanagi, Takeshi; Sugimura, Yoshihisa; Hayashi, Yoshitaka; Suzuki, Atsushi. 2019. "Short-Term High-Starch, Low-Protein Diet Induces Reversible Increase in β-cell Mass Independent of Body Weight Gain in Mice" Nutrients 11, no. 5: 1045. https://doi.org/10.3390/nu11051045

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