Next Article in Journal
Decreased Appetite is Associated with Sarcopenia-Related Outcomes in Acute Hospitalized Older Adults
Next Article in Special Issue
A Review of Dietary Therapy for IBD and a Vision for the Future
Previous Article in Journal
Local In Vivo Measures of Muscle Lipid and Oxygen Consumption Change in Response to Combined Vitamin D Repletion and Aerobic Training in Older Adults
Previous Article in Special Issue
Synbiotic Supplementation Containing Whole Plant Sugar Cane Fibre and Probiotic Spores Potentiates Protective Synergistic Effects in Mouse Model of IBD
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessReview

Dietary Factors in Sulfur Metabolism and Pathogenesis of Ulcerative Colitis

Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
BioTechnology Insititute, Department of Soil, Water & Climate, and Department of Plant & Microbial Biology, University of Minnesota, St. Paul, MN 55108, USA
Author to whom correspondence should be addressed.
Nutrients 2019, 11(4), 931;
Received: 24 March 2019 / Revised: 20 April 2019 / Accepted: 23 April 2019 / Published: 25 April 2019
(This article belongs to the Special Issue Nutrition in Inflammatory Bowel Disease (IBD))
PDF [1332 KB, uploaded 25 April 2019]
  |     |  


The biogeography of inflammation in ulcerative colitis (UC) suggests a proximal to distal concentration gradient of a toxin. Hydrogen sulfide (H2S) has long been considered one such toxin candidate, and dietary sulfur along with the abundance of sulfate reducing bacteria (SRB) were considered the primary determinants of H2S production and clinical course of UC. The metabolic milieu in the lumen of the colon, however, is the result of a multitude of factors beyond dietary sulfur intake and SRB abundance. Here we present an updated formulation of the H2S toxin hypothesis for UC pathogenesis, which strives to incorporate the interdependency of diet composition and the metabolic activity of the entire colon microbial community. Specifically, we suggest that the increasing severity of inflammation along the proximal-to-distal axis in UC is due to the dilution of beneficial factors, concentration of toxic factors, and changing detoxification capacity of the host, all of which are intimately linked to the nutrient flow from the diet. View Full-Text
Keywords: colon; high-sulfur foods; inflammation; metagenomics; microbiota; sulfur reducing colon; high-sulfur foods; inflammation; metagenomics; microbiota; sulfur reducing

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Teigen, L.M.; Geng, Z.; Sadowsky, M.J.; Vaughn, B.P.; Hamilton, M.J.; Khoruts, A. Dietary Factors in Sulfur Metabolism and Pathogenesis of Ulcerative Colitis. Nutrients 2019, 11, 931.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top