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Dietary Calcium Intake and Hypertension: Importance of Serum Concentrations of 25-Hydroxyvitamin D

1
Department of Environmental and Preventive Medicine, Graduate School of Medical Science, Kanazawa University, Ishikawa 920-8640, Japan
2
Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Ishikawa 920-8640, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(4), 911; https://doi.org/10.3390/nu11040911
Received: 8 April 2019 / Revised: 18 April 2019 / Accepted: 19 April 2019 / Published: 23 April 2019
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Abstract

The relationship among dietary calcium, hypertension and vitamin D status currently remains unclear. This population-based cross-sectional study examined the association between dietary calcium intake and hypertension and the influence of serum concentrations of 25-hydroxyvitamin D [25(OH)D] in Japanese subjects. A total of 619 subjects aged from 40 years were recruited. Dietary intake was measured using a validated brief self-administered diet history questionnaire. Hypertension was defined as the use of antihypertensive medication or a blood pressure of 140/90 mmHg. Serum concentrations of 25(OH)D were used as the biomarker of vitamin D status. The prevalence of hypertension and low serum 25(OH)D levels (<20 ng/mL) were 55 and 32%, respectively. Dietary calcium intake inversely correlated with hypertension in subjects with serum 25(OH)D levels higher than 20 ng/mL (OR: 0.995; 95% CI: 0.991, 0.999) but it was not significant in those with serum 25(OH)D levels of 20 ng/mL or lower. Furthermore, dietary vitamin D intake correlated with serum concentrations of 25(OH)D after adjustments for various confounding factors. The present results demonstrate that the regular consumption of calcium may contribute to the prevention and treatment of hypertension in subjects with a non-vitamin D deficiency and also that dietary vitamin D intake may effectively prevents this deficiency. View Full-Text
Keywords: hypertension; calcium; vitamin D; 25-hydroxyvitamin D hypertension; calcium; vitamin D; 25-hydroxyvitamin D
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Nakamura, H.; Tsujiguchi, H.; Hara, A.; Kambayashi, Y.; Miyagi, S.; Thi Thu Nguyen, T.; Suzuki, K.; Tao, Y.; Sakamoto, Y.; Shimizu, Y.; Yamamoto, N.; Nakamura, H. Dietary Calcium Intake and Hypertension: Importance of Serum Concentrations of 25-Hydroxyvitamin D. Nutrients 2019, 11, 911.

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