Micronutrients Deficiencies in 374 Severely Malnourished Anorexia Nervosa Inpatients
Abstract
:1. Introduction
2. Material and Methods
2.1. Patients and Study Design
2.2. Ethical Aspects
2.3. Measures and Procedure
2.4. Statistical Analysis
3. Results
3.1. Patients Characteristics
3.2. Prevalence of Micronutrients Deficiencies
4. Discussion
Limitation
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Clinical and Biological Parameters | N | AN-BP | AN-R | P |
---|---|---|---|---|
Patients (n, %) | 374 | 121 (32%) | 253 (68%) | |
Gender | 360 (96.3%) Women | 117 (96.7%) | 243 (96%) | NS |
14 (3.7%) Men | 4 (3.3%) | 10 (4.1%) | NS | |
Age (year) | 31.3 ± 12.9 | 29,41 (23.73, 37.09) | 26,22 (19.98, 38.29) | 0.029 |
Weight (kg) | 33.7 ± 5.9 | 34.40 (30.00, 39.10) | 32,40 (29.60, 36.80) | 0.048 |
Height (m) | 1.6 ± 0.07 | 1.64 (1.60, 1.68) | 1.62 (1.59, 1.68) | NS |
BMI (18.5–24.9 kg/m2) | 12.5 ± 1.7 | 12.80 (11.25, 14.20) | 12.30 (11.30, 13.50) | NS |
Fat Mass (g) | 3098 ± 1744 | 2715.00 (2236.75, 4073.73) | 2505.60 (2165.75, 3381.02) | NS |
Fat Mass (%) | 9702 ± 4057 | 8.60 (7.75, 12.45) | 8.50 (7.40, 9.43) | NS |
Disease duration (year) | 9.4 ± 9.2 | 10.00 (5.00, 16.00) | 4.50 (2.00, 12.00) | <0.001 |
Albumin (38–52 g/L) | 37 ± 6.8 | 38.00 (32.00, 42.00) | 37.75 (34.00, 41.00) | NS |
CRP (<5 mg/L) | 4 ± 14.5 | 0.71 (0.50, 1.20) | 0.70 (0.50, 1.45) | NS |
TSH (0.55–4.78 mUI/L) | 1.9 ± 1.5 | 1.35 (0.90, 2.23) | 1.62 (1.14, 2.35) | NS |
Ca (2.12–2.52 mmol/L) | 2.2 ± 0.17 | 2.25 (2.17, 2.38) | 2.22 (2.14, 2.30) | NS |
Ph (0.8–1.45 mmol/L) | 1.2 ± 1.6 | 1.15 (0.94, 1.27) | 1.15 (0.98, 1.31) | NS |
AST (15–37 UI/L) | 60.4 ± 116.3 | 28.00 (21.00, 38.00) | 29.00 (21.00, 54.00) | NS |
ALT (12–78 UI/L) | 109 ± 232.8 | 36.00 (26.25, 65.75) | 51.00 (30.00, 103.50) | 0.001 |
GGT (5–55 UI/L) | 63.1 ± 135.6 | 29.00 (18.00, 56.50) | 34.00 (20.00, 59.00) | NS |
ALP (46–116 UI/L) | 90.2 ± 105.3 | 70.00 (52.75, 95.50) | 70.00 (53.00, 94.00) | NS |
BNP (<100 ng/L) | 47.3 ± 68.4 | 20.00 (9.00, 46.00) | 31.00 (15.00, 52.75) | 0.021 |
LVEF (>50%) | 64.87 ± 7708 | 65.00 (57.00, 67.00) | 66.00 (61.00, 71.00) | 0.009 |
Deficiencies Number | % of Patients |
---|---|
None deficiency | 7.2% |
One deficiency | 28.3% |
Two deficiency | 33.2% |
Three deficiency | 18.8% |
Four and more deficiency | 12.6% |
Micronutrients | AN-BP | AN-R | p |
---|---|---|---|
Zinc (12.5–18 micromol/L) | 11.10 (9.05, 13.20) | 11.45 (9.50, 14.07) | NS |
Copper (12.7–22.2 micromol/L) | 15.25 (11.75, 17.70) | 13.50 (11.30, 16.72) | 0.022 |
Selenium (0.9–1.5 micromol/L) | 1.02 (0.83, 1.21) | 1.18 (1.00, 1.38) | <0.001 |
Vitamin B12 (197–77 1ng/L) | 516.00 (337.00, 804.00) | 608.50 (394.25, 976.75) | 0.036 |
Vitamin B9 (>3.90 microg/L) | 9.32 (6.18, 14.70) | 10.66 (6.19, 17.55) | NS |
Vitamin D (30–100 ng/mL) | 26.00 (15.75, 35.25) | 29.00 (20.75, 36.25) | NS |
Vitamin B1 (126–250 nmol/L) | 188.50 (150.00, 334.25) | 195.00 (148.00, 457.00) | NS |
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Hanachi, M.; Dicembre, M.; Rives-Lange, C.; Ropers, J.; Bemer, P.; Zazzo, J.-F.; Poupon, J.; Dauvergne, A.; Melchior, J.-C. Micronutrients Deficiencies in 374 Severely Malnourished Anorexia Nervosa Inpatients. Nutrients 2019, 11, 792. https://doi.org/10.3390/nu11040792
Hanachi M, Dicembre M, Rives-Lange C, Ropers J, Bemer P, Zazzo J-F, Poupon J, Dauvergne A, Melchior J-C. Micronutrients Deficiencies in 374 Severely Malnourished Anorexia Nervosa Inpatients. Nutrients. 2019; 11(4):792. https://doi.org/10.3390/nu11040792
Chicago/Turabian StyleHanachi, Mouna, Marika Dicembre, Claire Rives-Lange, Jacques Ropers, Pauline Bemer, Jean-Fabien Zazzo, Joël Poupon, Agnès Dauvergne, and Jean-Claude Melchior. 2019. "Micronutrients Deficiencies in 374 Severely Malnourished Anorexia Nervosa Inpatients" Nutrients 11, no. 4: 792. https://doi.org/10.3390/nu11040792