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The Relationship between Dietary Vitamin K and Depressive Symptoms in Late Adulthood: A Cross-Sectional Analysis from a Large Cohort Study

Medical Department, Geriatric Unit, Azienda ULSS (Unità Locale Socio Sanitaria) 3 “Serenissima”, 30031 Dolo-Mirano District, Italy
Aging Branch, Neuroscience Institute, National Research Council, 35128 Padua, Italy
National Institute of Gastroenterlogy, Research Hospital, IRCCS De Bellis, Castellana Grotte, 70013 Bari, Italy
South London and Maudsley NHS Foundation Trust, Denmark Hill, London SE5 8AZ, UK
Faculty of Health, Social care and Education, Anglia Ruskin University, Bishop Hall Lane, Chelmsford CM1 1SQ, UK
Institute of Psychiatry, Psychology and Neuroscience (IoPPN) King’s College London, De Crespigny Park, London SE5 8AF, UK
Primary Care Department, Azienda ULSS20 Verona, 37122 Verona, Italy
Primary Care Department, Azienda USL Toscana Sud Est, 58100 Grosseto, Italy
Primary Care Department, Aziendale AAS3 Alto Friuli – Collinare – Medio Friuli, 33013 Udine, Italy
University of Siena, 53100 Siena, Italy
Research and Development Unit, Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, CIBERSAM, 28029 Barcelona, Spain
New York State Psychiatric Institute, Columbia University, New York, NY 10027, USA
NICM Health Research Institute, University of Western Sydney, Penrith, NSW 2751, Australia
Division of Psychology and Mental Health, University of Manchester, Manchester M13 9PL, UK
The Cambridge Centre for Sport and Exercise Sciences, Department of Life Sciences, Anglia Ruskin University, Cambridge CB1 1PT, UK
Department of Neuroscience, University of Padova, 35122 Padova, Italy
Padova Neuroscience Center, University of Padova, 35122 Padova, Italy
Author to whom correspondence should be addressed.
Nutrients 2019, 11(4), 787;
Received: 27 January 2019 / Revised: 26 March 2019 / Accepted: 29 March 2019 / Published: 5 April 2019
(This article belongs to the Special Issue Diet and Mental Health)
Few studies assessed the associations between dietary vitamin K and depressive symptoms. We aimed to investigate the association between dietary vitamin K and depressive symptoms in a large cohort of North American People. In this cross-sectional analysis, 4,375 participants that were aged 45–79 years from the Osteoarthritis Initiative were included. Dietary vitamin K intake was collected through a semi-quantitative food frequency questionnaire and categorized in quartiles. Depressive symptoms were diagnosed using the 20-item Center for Epidemiologic Studies-Depression (CES-D) ≥ 16. To investigate the associations between vitamin K intake and depressive symptoms, logistic regression analysis were run, which adjusted for potential confounders. Overall, 437 (=10%) subjects had depressive symptoms. After adjusting for 11 confounders, people with the highest dietary vitamin K intake had lower odds of having depressive symptoms (OR = 0.58; 95%CI: 0.43–0.80). This effect was only present in people not taking vitamin D supplementation. In conclusion, higher dietary vitamin K intake was significantly associated with a lower presence of depressive symptoms, also after accounting for potential confounders. Future longitudinal research is required to explore the directionality of the association. View Full-Text
Keywords: vitamin K; depression; Osteoarthritis Initiative; mental health; diet; nutrition vitamin K; depression; Osteoarthritis Initiative; mental health; diet; nutrition
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Bolzetta, F.; Veronese, N.; Stubbs, B.; Noale, M.; Vaona, A.; Demurtas, J.; Celotto, S.; Cacco, C.; Cester, A.; Caruso, M.G.; Reddavide, R.; Notarnicola, M.; Maggi, S.; Koyanagi, A.; Fornaro, M.; Firth, J.; Smith, L.; Solmi, M. The Relationship between Dietary Vitamin K and Depressive Symptoms in Late Adulthood: A Cross-Sectional Analysis from a Large Cohort Study. Nutrients 2019, 11, 787.

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