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Nutrients
Volume 11
Issue 3
10.3390/nu11030641
Review Report
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Article
Peer-Review Record

Cyanidin Increases the Expression of Mg2+ Transport Carriers Mediated by the Activation of PPARα in Colonic Epithelial MCE301 Cells

Nutrients 2019, 11(3), 641; https://doi.org/10.3390/nu11030641
by Yui Takashina 1, Aya Manabe 1, Yoshiaki Tabuchi 2 and Akira Ikari 1,*
Reviewer 1: Anonymous
Reviewer 2:
Bernard Fioretti
Nutrients 2019, 11(3), 641; https://doi.org/10.3390/nu11030641
Submission received: 14 February 2019 / Revised: 13 March 2019 / Accepted: 13 March 2019 / Published: 16 March 2019

Round 1

Reviewer 1 Report

Line 66- May be correcto to black soybean; soybean does not have anthocyanins 

Reference 19 in the introduction does not correspond to the sentence

Most of the results were obtained with cyanidin but the biological relevance should be discussed. In nature the main form of cyanidin is cyanidin-3-glucose, so conclusions about the effect of anthocyanins-rich food consumption in Mg transport should be taken with care.


Author Response

We thank you very much for your careful reading of our manuscript and valuable comments.  

Following your suggestion, we modified the Discussion. Please see line 344.

Reviewer 2 Report

Dear Editors,

 

the paper of Takashina et al.,  described the effects, in vitro,  of cyanidin in magnesium intestinal transport (TRPM6 and CNNM4) at transcriptional, translational and functional level. The date is innovative and the message is important to understand the bio-aviability of magnesium and how this is modulated by exogen substances such as cyanidin.

 

Only few questions are needed:

The TER recording displays no change in resistance, but the influx or efflux of magnesium is expected to impact on resistence. A discussion of this aspect is needed.

Could be helpful to insert a final scheme for a better presentation of the models proposed

Could be helpful to integrate in the method section a table of pharmacological tool used to better read the paper


Author Response

We thank you very much for your careful reading of our manuscript and valuable comments.


Comment 1

The TER recording displays no change in resistance, but the influx or efflux of magnesium is expected to impact on resistence. A discussion of this aspect is needed.

 

Answer

  Following your suggestion, we modified the Discussion.  Please see line 335.

 

Comment 2

Could be helpful to insert a final scheme for a better presentation of the models proposed

 

Answer

  Following your suggestion, we added a predicted scheme. Please see new figure 9.

 

Comment 3

Could be helpful to integrate in the method section a table of pharmacological tool used to better read the paper.

 

Answer

  Following your suggestion, we added a table of pharmacological tool. Please see line 93.

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