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Glycemia Lowering Effect of an Aqueous Extract of Hedychium coronarium Leaves in Diabetic Rodent Models

1
School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan
2
Institute of Food Safety and Health Risk Assessment, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei 112, Taiwan
3
Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
4
Department of Physiology, School of Medicine, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
5
Graduate Institute of Veterinary Pathobiology, National Chung Hsing University, Taichung 402, Taiwan
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(3), 629; https://doi.org/10.3390/nu11030629
Received: 7 February 2019 / Revised: 7 March 2019 / Accepted: 11 March 2019 / Published: 14 March 2019
(This article belongs to the Special Issue Dietary Intake and Type 2 Diabetes)
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Abstract

Hedychium coronarium has a long history of use worldwide as a food and in folk medicine. In this study, we aimed to investigate the effect of an aqueous extract of H. coronarium leaves (HC) on type 2 diabetes mellitus (T2DM). Two types of animal models were used in this study: Streptozotocin (STZ)-induced T2DM (Wistar rats; N = 8) and C57BKSdb/db mice (N = 5). After treatment with HC for 28 days, glucose tolerance improved in both of the diabetic animal models. As significant effects were shown after 14 days of treatment in the STZ-induced T2DM model, we carried out the experiments with it. After 28 days of treatment with HC, the levels of cholesterol, triglyceride, high-density lipoprotein, and low-density lipoprotein were significantly improved in the STZ-induced T2DM model. The lesions degree of islet β-cells was decreased after the HC treatment. Although the insulin level increased moderately, the aldosterone level was significantly decreased in the HC-treated groups, suggesting that aldosterone might play an important role in this effect. In summary, HC is a natural product and it is worth exploring its effect on T2DM. View Full-Text
Keywords: Hedychium coronarium; type 2 diabetes; aldosterone; streptozotocin; metabolic syndrome; folk medicine Hedychium coronarium; type 2 diabetes; aldosterone; streptozotocin; metabolic syndrome; folk medicine
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Tse, L.-S.; Liao, P.-L.; Tsai, C.-H.; Li, C.-H.; Liao, J.-W.; Kang, J.-J.; Cheng, Y.-W. Glycemia Lowering Effect of an Aqueous Extract of Hedychium coronarium Leaves in Diabetic Rodent Models. Nutrients 2019, 11, 629.

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