Glycemia Lowering Effect of an Aqueous Extract of Hedychium coronarium Leaves in Diabetic Rodent Models
AbstractHedychium coronarium has a long history of use worldwide as a food and in folk medicine. In this study, we aimed to investigate the effect of an aqueous extract of H. coronarium leaves (HC) on type 2 diabetes mellitus (T2DM). Two types of animal models were used in this study: Streptozotocin (STZ)-induced T2DM (Wistar rats; N = 8) and C57BKSdb/db mice (N = 5). After treatment with HC for 28 days, glucose tolerance improved in both of the diabetic animal models. As significant effects were shown after 14 days of treatment in the STZ-induced T2DM model, we carried out the experiments with it. After 28 days of treatment with HC, the levels of cholesterol, triglyceride, high-density lipoprotein, and low-density lipoprotein were significantly improved in the STZ-induced T2DM model. The lesions degree of islet β-cells was decreased after the HC treatment. Although the insulin level increased moderately, the aldosterone level was significantly decreased in the HC-treated groups, suggesting that aldosterone might play an important role in this effect. In summary, HC is a natural product and it is worth exploring its effect on T2DM. View Full-Text
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Tse, L.-S.; Liao, P.-L.; Tsai, C.-H.; Li, C.-H.; Liao, J.-W.; Kang, J.-J.; Cheng, Y.-W. Glycemia Lowering Effect of an Aqueous Extract of Hedychium coronarium Leaves in Diabetic Rodent Models. Nutrients 2019, 11, 629.
Tse L-S, Liao P-L, Tsai C-H, Li C-H, Liao J-W, Kang J-J, Cheng Y-W. Glycemia Lowering Effect of an Aqueous Extract of Hedychium coronarium Leaves in Diabetic Rodent Models. Nutrients. 2019; 11(3):629.Chicago/Turabian Style
Tse, Ling-Shan; Liao, Po-Lin; Tsai, Chi-Hao; Li, Ching-Hao; Liao, Jiunn-Wang; Kang, Jaw-Jou; Cheng, Yu-Wen. 2019. "Glycemia Lowering Effect of an Aqueous Extract of Hedychium coronarium Leaves in Diabetic Rodent Models." Nutrients 11, no. 3: 629.
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