The Impact of Intermittent Fasting (Ramadan Fasting) on Psoriatic Arthritis Disease Activity, Enthesitis, and Dactylitis: A Multicentre Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Ethical Approval
2.2. Patients’ Selection and Inclusion
2.3. Measures and Outcomes
2.4. Statistical Analysis
3. Results
3.1. Study Population
3.2. Impact of Intermittent Fasting on Patient Weight
3.3. Impact of Intermittent Fasting on Biochemical Parameters
3.4. Impact of Intermittent Fasting on PsA Disease Activity Scores, Enthesitis and Dactylitis
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Parameter | Value | |
---|---|---|
Age (years) | 43.32 ± 7.81 (median 43) | |
Gender (%) | Male | 14 (37.8%) |
Female | 23 (62.2%) | |
BMI (kg/m2) | 26.16 ± 1.59 | |
Disease duration (years) | 7.59 ± 3.78 (median 8) | |
Family history positive for PsA | 15 (40.5%) | |
Country of origin | Egypt | 10 (27.0%) |
Morocco | 6 (16.2%) | |
Algeria | 5 (13.5%) | |
Turkey | 5 (13.5%) | |
Israel | 3 (8.1%) | |
Kurdistan | 3 (8.1%) | |
Afghanistan | 2 (5.4%) | |
Cyprus | 2 (5.4%) | |
Jordan | 1 (2.7%) | |
Enthesitis | 24 (64.9%) | |
Dactylitis | 13 (35.1%) | |
Axial involvement | 13 (35.1%) | |
Peripheral arthritis | 12 (32.4%) | |
Treatment | Methotrexate | 3 (8.1%) |
TNF-α blockers | 28 (75.7%) | |
IL-17 blockers | 6 (16.2%) |
Parameter | Before Fasting | After Fasting |
---|---|---|
WBC (N/μL) | 7850 ± 430 | 7750 ± 510 |
Neutrophils (109/L) | 5.4 ± 0.8 | 5.4 ± 0.6 |
Lymphocytes (109/L) | 2.7 ± 0.4 | 2.8 ± 0.4 |
RBC (106/μL) | 5.6 ± 1.2 | 5.7 ± 1.1 |
MCV (fL) | 89.8 ± 2.3 | 90 ± 2.1 |
Hb (g/dL) | 14.8 ± 1.3 | 14.7 ± 1.4 |
PLT (1,000/μL) | 215 ± 32 | 216 ± 28 |
Creatinine (mg/dL) | 0.7 ± 0.1 | 0.7 ± 0.1 |
Urea (mg/dL) | 7.3 ± 0.9 | 6.9 ± 1.2 |
AST (IU/L) | 37 ± 5.2 | 38 ± 4 |
ALT (IU/L) | 35 ± 8.3 | 36 ± 6.7 |
GGT (IU/L) | 26 ± 5.6 | 26 ± 4 |
ALK (IU/L) | 48 ± 8 | 47 ± 6.4 |
CRP (mg/dL) | 14.1 ± 4.7 | 12.2 ± 4.5 |
Independent Variables | Coefficient | Standard Error (SE) | t | p-Value | rpartial | rsemipartial |
---|---|---|---|---|---|---|
Delta BASDAI | ||||||
(Constant) | 5.04 | |||||
Age | −0.05 | 0.03 | −1.63 | 0.1480 | −0.52 | 0.48 |
Therapy | 0.58 | 0.50 | 1.15 | 0.2883 | 0.40 | 0.34 |
Gender | 0.33 | 0.51 | 0.65 | 0.5397 | 0.24 | 0.19 |
BMI | −0.14 | 0.15 | −0.95 | 0.3732 | −0.34 | 0.28 |
Delta CRP | ||||||
(Constant) | 3.98 | |||||
Age | −0.03 | 0.03 | −0.83 | 0.4132 | −0.15 | 0.14 |
Therapy | −0.46 | 0.53 | −0.86 | 0.3942 | −0.15 | 0.15 |
Gender | 0.48 | 0.57 | 0.85 | 0.3997 | 0.15 | 0.15 |
BMI | −0.01 | 0.18 | −0.043 | 0.9658 | −0.01 | 0.01 |
Delta DAPSA | ||||||
(Constant) | 12.06 | |||||
Age | −0.05 | 0.05 | −1.10 | 0.2785 | −0.19 | 0.19 |
Therapy | −0.66 | 0.78 | −0.86 | 0.3991 | −0.15 | 0.14 |
Gender | 0.94 | 0.83 | 1.14 | 0.2627 | 0.20 | 0.19 |
BMI | −0.25 | 0.27 | −0.93 | 0.3601 | −0.16 | 0.16 |
Delta Dactylitis Severity Score | ||||||
(Constant) | −4.13 | |||||
Age | 0.01 | 0.02 | 0.41 | 0.6845 | 0.07 | 0.07 |
Therapy | −0.32 | 0.30 | −1.04 | 0.3063 | −0.18 | 0.17 |
Gender | −0.52 | 0.32 | −1.60 | 0.1186 | −0.27 | 0.26 |
BMI | 0.24 | 0.11 | 2.28 | 0.0293 | 0.37 | 0.37 |
Delta Leeds Enthesitis Index | ||||||
(Constant) | −1.71 | |||||
Age | 0.02 | 0.01 | 1.08 | 0.2939 | 0.24 | 0.21 |
Therapy | 0.57 | 0.26 | 2.22 | 0.0390* | 0.45 | 0.44 |
Gender | −0.19 | 0.27 | −0.72 | 0.4833 | −0.16 | 0.14 |
BMI | 0.02 | 0.08 | 0.23 | 0.8212 | 0.05 | 0.04 |
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Adawi, M.; Damiani, G.; Bragazzi, N.L.; Bridgewood, C.; Pacifico, A.; Conic, R.R.Z.; Morrone, A.; Malagoli, P.; Pigatto, P.D.M.; Amital, H.; et al. The Impact of Intermittent Fasting (Ramadan Fasting) on Psoriatic Arthritis Disease Activity, Enthesitis, and Dactylitis: A Multicentre Study. Nutrients 2019, 11, 601. https://doi.org/10.3390/nu11030601
Adawi M, Damiani G, Bragazzi NL, Bridgewood C, Pacifico A, Conic RRZ, Morrone A, Malagoli P, Pigatto PDM, Amital H, et al. The Impact of Intermittent Fasting (Ramadan Fasting) on Psoriatic Arthritis Disease Activity, Enthesitis, and Dactylitis: A Multicentre Study. Nutrients. 2019; 11(3):601. https://doi.org/10.3390/nu11030601
Chicago/Turabian StyleAdawi, Mohammad, Giovanni Damiani, Nicola Luigi Bragazzi, Charlie Bridgewood, Alessia Pacifico, Rosalynn R. Z. Conic, Aldo Morrone, Piergiorgio Malagoli, Paolo Daniele Maria Pigatto, Howard Amital, and et al. 2019. "The Impact of Intermittent Fasting (Ramadan Fasting) on Psoriatic Arthritis Disease Activity, Enthesitis, and Dactylitis: A Multicentre Study" Nutrients 11, no. 3: 601. https://doi.org/10.3390/nu11030601