Next Article in Journal
Dianthus superbus Improves Glomerular Fibrosis and Renal Dysfunction in Diabetic Nephropathy Model
Previous Article in Journal
A Preventive Prebiotic Supplementation Improves the Sweet Taste Perception in Diet-Induced Obese Mice
Open AccessArticle

Growth, Protein and Energy Intake in Children with PKU Taking a Weaning Protein Substitute in the First Two Years of Life: A Case-Control Study

Birmingham Women’s and Children’s Hospital NHS Foundation Trust, Birmingham B4 6NH, UK
Bradford Teaching Hospitals NHS Trust, Bradford BD9 6RJ, UK
Royal Hospital for Children Glasgow G51 4TF, UK
Danone Early Life Nutrition, Macquarie Park, New South Wales, Australia
Author to whom correspondence should be addressed.
Nutrients 2019, 11(3), 552;
Received: 21 December 2018 / Revised: 20 February 2019 / Accepted: 27 February 2019 / Published: 5 March 2019
Growth issues have been observed in young children with phenylketonuria (PKU), but studies are conflicting. In infancy, there is an increasing trend to introduce a second-stage semi-solid weaning protein substitute (WPS) but there is concern that this may not meet energy requirements. In this longitudinal, prospective study, 20 children with PKU transitioning to a WPS, and 20 non-PKU controls were observed monthly from weaning commencement (4–6 months) to 12 m and at 15, 18 and 24 months of age for: weight, length, head circumference, body mass index (BMI), energy and macronutrient intake. Growth parameters were within normal range at all ages in both groups with no significant difference in mean z-scores except for accelerated length in the PKU group. No child with PKU had z-scores < −2 for any growth parameter at age 2 years. Total protein and energy intake in both groups were similar at all ages; however, from 12–24 months in the PKU group, the percentage of energy intake from carbohydrate increased (60%) but from fat decreased (25%) and inversely for controls (48% and 36%). In PKU, use of low volume WPS meets Phe-free protein requirements, facilitates transition to solid foods and supports normal growth. Further longitudinal study of growth, body composition and energy/nutrient intakes in early childhood are required to identify any changing trends. View Full-Text
Keywords: Phenylketonuria (PKU); growth; protein substitute; weaning Phenylketonuria (PKU); growth; protein substitute; weaning
Show Figures

Figure 1

MDPI and ACS Style

Evans, S.; Daly, A.; Wildgoose, J.; Cochrane, B.; Chahal, S.; Ashmore, C.; Loveridge, N.; MacDonald, A. Growth, Protein and Energy Intake in Children with PKU Taking a Weaning Protein Substitute in the First Two Years of Life: A Case-Control Study. Nutrients 2019, 11, 552.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop