Next Article in Journal
The Development and Evaluation of a Diet Quality Index for Asian Toddlers and Its Perinatal Correlates: The GUSTO Cohort Study
Previous Article in Journal
Hydrangea serrata (Thunb.) Ser. Extract Attenuate UVB-Induced Photoaging through MAPK/AP-1 Inactivation in Human Skin Fibroblasts and Hairless Mice
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nutrients
Volume 11
Issue 3
10.3390/nu11030534
nutrients-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Pregnancy Loss and Iodine Status: The LIFE Prospective Cohort Study

by
James L. Mills
1,*,
Mehnaz Ali
1,
Germaine M. Buck Louis
2,3,
Kurunthachalam Kannan
4,
Jennifer Weck
2,
Yanjian Wan
4,
Joe Maisog
5,
Andreas Giannakou
1 and
Rajeshwari Sundaram
6
1
Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
2
Office of the Director, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
3
Dean’s Office, College of Health and Human Services, George Mason University, Fairfax, VA 22030, USA
4
Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA
5
Glotech, Inc., Rockville, MD 20850, USA
6
Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(3), 534; https://doi.org/10.3390/nu11030534
Submission received: 8 February 2019 / Revised: 21 February 2019 / Accepted: 26 February 2019 / Published: 1 March 2019
Versions Notes

Abstract

Iodine deficiency in pregnancy is a common problem in the United States and parts of Europe, but whether iodine deficiency is associated with increased pregnancy loss has not been well studied. The LIFE study provided an excellent opportunity to examine the relationship between iodine status and pregnancy loss because women were monitored prospectively to ensure excellent ascertainment of conceptions. The LIFE study, a population-based prospective cohort study, monitored 501 women who had discontinued contraception within two months to become pregnant; 329 became pregnant, had urinary iodine concentrations measured on samples collected at enrollment, and were followed up to determine pregnancy outcomes. Of the 329, 196 had live births (59.5%), 92 (28.0%) had losses, and 41 (12.5%) withdrew or were lost to follow up. Urinary iodine concentrations were in the deficiency range in 59.6% of the participants. The risk of loss, however, was not elevated in the mildly deficient group (hazard ratio 0.69, 95% confidence interval 0.34, 1.38), the moderately deficient group (hazard ratio 0.81, 95% confidence interval 0.43, 1.51), or the severely deficient group (hazard ratio 0.69, 95% confidence interval 0.32, 1.50). Iodine deficiency, even when moderate to severe, was not associated with increased rates of pregnancy loss. This study provides some reassurance that iodine deficiency at levels seen in many developed countries does not increase the risk of pregnancy loss.
Keywords: iodine; pregnancy loss; spontaneous abortion; miscarriage; fetal loss iodine; pregnancy loss; spontaneous abortion; miscarriage; fetal loss

Share and Cite

MDPI and ACS Style

Mills, J.L.; Ali, M.; Buck Louis, G.M.; Kannan, K.; Weck, J.; Wan, Y.; Maisog, J.; Giannakou, A.; Sundaram, R. Pregnancy Loss and Iodine Status: The LIFE Prospective Cohort Study. Nutrients 2019, 11, 534. https://doi.org/10.3390/nu11030534

AMA Style

Mills JL, Ali M, Buck Louis GM, Kannan K, Weck J, Wan Y, Maisog J, Giannakou A, Sundaram R. Pregnancy Loss and Iodine Status: The LIFE Prospective Cohort Study. Nutrients. 2019; 11(3):534. https://doi.org/10.3390/nu11030534

Chicago/Turabian Style

Mills, James L., Mehnaz Ali, Germaine M. Buck Louis, Kurunthachalam Kannan, Jennifer Weck, Yanjian Wan, Joe Maisog, Andreas Giannakou, and Rajeshwari Sundaram. 2019. "Pregnancy Loss and Iodine Status: The LIFE Prospective Cohort Study" Nutrients 11, no. 3: 534. https://doi.org/10.3390/nu11030534

APA Style

Mills, J. L., Ali, M., Buck Louis, G. M., Kannan, K., Weck, J., Wan, Y., Maisog, J., Giannakou, A., & Sundaram, R. (2019). Pregnancy Loss and Iodine Status: The LIFE Prospective Cohort Study. Nutrients, 11(3), 534. https://doi.org/10.3390/nu11030534

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop